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MetabolomicsUntargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma
Feline chronic enteropathy (CE) is a common gastrointestinal disorder in cats and mainly comprises inflammatory bowel disease (IBD) and small cell lymphoma (SCL). Differentiation between IBD and SCL can be diagnostically challenging. We characterized the fecal metabolome of 14 healthy cats and 22 ca...
2021-07-13 | MTBLS440 | MetaboLights
UnknownAssociation of body mass index and survival in pediatric leukemia: a meta-analysis.
Not available
S-EPMC6546230 | biostudies-literature
UnknownFlavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins.
Not available
S-EPMC7902656 | biostudies-literature
GenomicsTat controls RNA Polymerase II and the epigenetic landscape to precisely rewire cellular transcriptional programs (ChIP-Seq)
Transcription factors mediate precise regulation of gene expression programs to modulate key biological processes. In addition to controlling HIV transcription, Tat appears to modulate cellular transcription to alter the biology of target immune cells and generate a permissive state for HIV infecti...
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-65687 | biostudies-arrayexpress
GenomicsDeregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [ChIP-seq]
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of negative feedback through Sprouty gene deletion rem...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-64190 | biostudies-arrayexpress
ProteomicsHIV-Tat treatment of human neurons in vitro over time: towards a model for the molecular pathology of HIV-associated neurocognitive disorders (~90% cell culture confluence dataset)
We have used LC-MSMS discovery proteomics to identify the quantitative, cell-wide changes that occur when non-transformed, differentiated human neurons are treated with HIV-Tat over time. This may represent a novel cell culture model for initial HIV-associated neurocognitive disorder progression.
ORGANISM(S): Homo sapiens (Human) 
2017-05-19 | PXD006314 | Pride
Hiv-tat Hiv associated neurocognitive disorders Human neuronal cells Lcmsms 
ProteomicsHIV-Tat treatment of human neurons in vitro over time: towards a model for the molecular pathology of HIV-associated neurocognitive disorders (~70% cell culture confluence dataset)
We have used LC-MSMS discovery proteomics to identify the quantitative, cell-wide changes that occur when non-transformed, differentiated human neurons are treated with HIV-Tat over time. This may represent a novel cell culture model for initial HIV-associated neurocognitive disorder progression.
ORGANISM(S): Homo sapiens (Human) 
2017-05-19 | PXD006332 | Pride
Hiv-tat Hiv associated neurocognitive disorders Human neuronal cells Lcmsms 
TranscriptomicsDeregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [RNA-seq]
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of negative feedback through Sprouty gene deletion rem...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-63497 | biostudies-arrayexpress
TranscriptomicsMicroRNA miR-16 is anti-proliferative in enterocytes and exhibits diurnal rhythmicity in intestinal crypts
This is the first report to document circadian rhythmicity of specific microRNAs in rat jejunum. Our data provide a link between the anti-proliferative microRNA miR-16 and the intestinal proliferation rhythm and point to miR-16 as an important regulator of proliferation in jejunal crypts. This funct...
ORGANISM(S): Rattus norvegicus 
2010-08-13 | E-GEOD-20603 | biostudies-arrayexpress
GenomicsGenome-wide map of DNaseI hypersensitivity in mouse erythroid cells.
We generated genome-wide maps of DNaseI hypersensitivity in mouse erythroid cells by DNase-Seq. Examination of DNaseI hypersensitivity in mouse erythroid cells.
ORGANISM(S): Mus musculus 
2012-01-30 | E-GEOD-27919 | biostudies-arrayexpress
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