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TranscriptomicsSingle-cell RNA sequencing of colorectal cancer
We profile single cells from patients with colorectum cancer using Chromium 3’ and 5’ single-cell RNA-sequencing. Patients EXT001, EXT009, and EXT012 from the KUL dataset were first analyzed by Lee et al., 2020, and the raw data are available in ArrayExpress under the accession codes E-MTAB-8410 and...
ORGANISM(S): Homo sapiens 
2022-09-16 | E-MTAB-9934 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing on posterior intestinal tracts and surrounding tissues dissected from living embryos in 4 time-windows from 3.5 hours to 10 hours post-laying
The aim of this experiment was to generate a scRNA-seq dataset that would allow us to follow the emergence of the adult midgut progenitor cells within the embryonic midgut cell population.
ORGANISM(S): Drosophila melanogaster 
2024-10-17 | E-MTAB-13247 | biostudies-arrayexpress
TranscriptomicsscRNAseq of CD45+ FACS sorted cells from 5555_V600-BRAFmut mouse melanoma tumours treated with Ranolazine and anti-PD
Single cell RNAseq libraries generation of the sub-population of the immune infiltrate of 5555_V600-BRAFmut mouse melanoma tumours. The selected populations have been isolated by using CD45-APC labelling and FACS-sorted isolated. Tumours were treated with Ranolazine (an FAO inhibitor) and anti-PD-L1...
ORGANISM(S): Mus musculus 
2023-06-28 | E-MTAB-12315 | biostudies-arrayexpress
TranscriptomicsJNK activity provides an intrinsic adaptive phenotype to naive pluripotent cells
Cellular adaptation requires a delicate balance between preserving distinct cell identity while maintaining the ability to sense and respond to environmental changes. This is particularly critical during developmental transitions, where cells must adapt to ensure survival without losing their funct...
ORGANISM(S): Mus musculus 
2026-10-07 | E-MTAB-15979 | biostudies-arrayexpress
TranscriptomicsPosttranscriptional reprogramming controls MASLD progression through chronic ER stress adaptation (Riboseq)
Metabolic dysfunction-associated steatohepatitis (MASH) and its progression to hepatocellular carcinoma remain major clinical challenges. Chronic endoplasmic reticulum (ER) stress, induced by sustained high-fat diet (HFD) intake, promotes hepatic inflammation, lipid accumulation, and hepatocellular ...
ORGANISM(S): Mus musculus 
2026-03-05 | E-MTAB-16293 | biostudies-arrayexpress
GenomicsThe transcription factor GATA6 allows self-renewal of colon adenoma stem cells by repressing BMP gene expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-05-20 | E-GEOD-56897 | biostudies-arrayexpress
TranscriptomicsCRC micrometastasis generated by AKP MTOs resolved by single cell RNAseq
Longitudinal single cell RNA-expression analysis of tumor cells along metastatic relapse. AKP mouse tumor organoids (MTOs) were implanted in the caecum and left to metastasize into the liver. Livers were collected at different timepoints post-injection and GFP+ CD45- cells were sorted in 96-well sma...
ORGANISM(S): Mus musculus 
2022-11-18 | E-MTAB-11981 | biostudies-arrayexpress
TranscriptomicsPosttranscriptional reprogramming controls MASLD progression through chronic ER stress adaptation (RNAseq 2)
Metabolic dysfunction-associated steatohepatitis (MASH) and its progression to hepatocellular carcinoma remain major clinical challenges. Chronic endoplasmic reticulum (ER) stress, induced by sustained high-fat diet (HFD) intake, promotes hepatic inflammation, lipid accumulation, and hepatocellular ...
ORGANISM(S): Mus musculus 
2026-03-05 | E-MTAB-16294 | biostudies-arrayexpress
TranscriptomicsPosttranscriptional reprogramming controls MASLD progression through chronic ER stress adaptation (RNAseq)
Metabolic dysfunction-associated steatohepatitis (MASH) and its progression to hepatocellular carcinoma remain major clinical challenges. Chronic endoplasmic reticulum (ER) stress, induced by sustained high-fat diet (HFD) intake, promotes hepatic inflammation, lipid accumulation, and hepatocellular ...
ORGANISM(S): Mus musculus 
2026-03-05 | E-MTAB-16295 | biostudies-arrayexpress
TranscriptomicsscRNAseq of mouse colorectal organoids in FOLFIRI treatment
The aim of the experiment is to elucidate changes in tumor heterogeneity upon chemotherapy treatment. The experiment includes non-treated samples, samples right after chemotherapy treatment (FOLFIRI) and organoids recovered from FOLFIRI. It was conducted in two different genetic backgrounds, AKP (Ap...
ORGANISM(S): Mus musculus 
2022-05-13 | E-MTAB-11145 | biostudies-arrayexpress
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