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ProteomicsMapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy
Identification of physiologically relevant peptide vaccine targets calls for the direct analysis of the entirety of naturally presented human leukocyte antigen (HLA) ligands, termed the HLA ligandome. In this study, we implemented this direct approach using immunoprecipitation and mass spectrometry ...
ORGANISM(S): Homo sapiens (Human) 
2019-10-14 | PXD015748 | Pride
Acute myeloid leukemia Lc-msms 
TranscriptomicsHLA ligand profiles of primary renal cell carcinoma maintained in metastases.sue
In recent years, several approaches have been taken in the peptide-based immunotherapy of metastatic renal cell carcinoma (RCC), although little is known about HLA presentation on metastases compared to primary tumor and normal tissue of RCC. In this study we compared primary tumor, normal tissue an...
ORGANISM(S): Homo sapiens 
2008-09-03 | E-GEOD-12606 | biostudies-arrayexpress
ProteomicsThe antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapy
Direct analysis of HLA-presented antigens by mass spectrometry provides a comprehensive view on the antigenic landscape of different tissues/malignancies and enables the identification of novel, pathophysiologically relevant T-cell epitopes. Here, we present a systematic and comparative study of the...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD035324 | Pride
Human leukocyte antigens T-lymphocytes Mass spectrometry Immunotherapy Ligands Peptides Antigens Multiple myeloma 
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