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TranscriptomicsRNA-seq of murine CD4 T cells after pentanoate treatment compared to untreated control
To analyse the influence of pentanoate on the differentiation of naive CD4 T cells under Th17 inducing conditions, murine CD4 T cells were isolated from spleen and lymphnodes of FIR/TIGER mice (IL-10 (GFP) - Foxp3 (RFP) - Reporter mice). The T cells were kept for 3 days under Th17 inducing condition...
ORGANISM(S): Mus musculus 
2019-01-15 | E-MTAB-6114 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation with p53-antibody of human osteosarcoma cell line Saos-2 infected with adenomviruses encoding GFP, or GFP with p53 H1 helix mutants EL or RE
ChIP-chip study using Saos-2 cell line infected with adenoviruses encoding GFP (Mock) or GFP together with the p53 H1 helix mutants EL or RE. DNA-protein-complexes were precipitated with monoclonal p53-antibody (clone DO-1). Mock-chromatin was immunoprecipitated in the absence of antibody.
Three ...
ORGANISM(S): Homo sapiens 
2010-05-13 | E-MEXP-1748 | biostudies-arrayexpress
GenomicsCharacterization of the p53 cistrome - DNA binding cooperativity dissects p53's tumor suppressor functions
p53 wildtype or complementing DNA binding cooperativity versions (EE, RR, EE/RR) were overexpressed in SAOS cells and 18h later harvested to perform ChIP with an p53-specific antibody. The enriched DNA fragments were purified and identified by high throughput sequencing.
ORGANISM(S): Homo sapiens 
2014-02-14 | E-MTAB-1394 | biostudies-arrayexpress
TranscriptomicsCharacterization of the p53 cistrome - DNA binding cooperativity dissects p53's tumor suppressor functions - Expression profiling
P53 wildtype or complementing DNA binding cooperativity versions (p53EE, p53RR, p53EE/RR) were overexpressed in SAOS cells. After 18h cells were harvested and subjected to expression profiling.
ORGANISM(S): Homo sapiens 
2014-02-14 | E-MTAB-1403 | biostudies-arrayexpress
MetabolomicsTargeting PI3K inhibitor resistance in breast cancer with metabolic drugs

Activating PIK3CA mutations, present in up to 40% of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (Her2-) breast cancer (BC) patients, can be effectively targeted with the alpha isoform-specific PI3K inhibitor Alpelisib. This treatment significantly improves ...

2026-08-21 | MTBLS11671 | MetaboLights
TranscriptomicsAltered glycogen metabolism causes hepatomegaly following an Atg7 deletion
Autophagy is a lysosomal degradation process involved in the turnover of organelles or other cell constituents, in providing sources for energy production under starving conditions, and in cell metabolism. A key protein in the macroautophagic machinery is the autophagy related protein (Atg) 7. Const...
ORGANISM(S): Mus musculus 
2016-07-12 | E-MTAB-4389 | biostudies-arrayexpress
TranscriptomicsRNA-seq of murine spleen B-cells after pentanoate treatment compared to untreated control
We tested the influence of pentanoate on B cells by treatment of CpG-stimulated B cells in vitro. We isolated naive B cells from FIR/TIGER mice (IL-10 (GFP) - Foxp3 (RFP) - Reporter mice) from spleen. Cells were cultured in presence of 5 µg/ml CpG 2395. 24h after CpG-stimulation, B cells were treate...
ORGANISM(S): Mus musculus 
2019-01-15 | E-MTAB-6115 | biostudies-arrayexpress
GenomicsSP1/2/3 and NfY cooccurency in MEFs
Investigation of the binding behaviour of Sp1, Sp2, Sp3 and NF-ya, NF-yb and NF-yc in mouse embryonic fibroblasts and of Sp1, Sp2 and Sp3 in HEK-293 cells reveals distinct binding of the seemingly similar transcription factors Sp1/3 and Sp2.
ORGANISM(S): Mus musculus 
2015-01-30 | E-MTAB-2970 | biostudies-arrayexpress
ProteomicsIdentification of phosphorylation sites regulated by lysophosphatidic acid (LPA) in OCMI91s ovarian cancer cells
Elevated levels of lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high grade serous cancer (HGSC) and are associated with a short relapse-free survival. LPA is known to support the metastatic spread of cancer cells by activating a multitude of signaling pathways through G-p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-25 | MSV000091146 | MassIVE
TranscriptomicsThe transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization
RNAseq of peritoneal macrophages from patients with non-malignent peritoneal afflictions.
ORGANISM(S): Homo sapiens 
2016-09-27 | E-MTAB-4764 | biostudies-arrayexpress
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