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ProteomicsSTK19 drives transcription-coupled nucleotide excision repair by stimulating Pol II ubiquitylation and TFIIH recruitment
DNA damage forms a major obstacle for gene transcription by RNA polymerase II (Pol II). Transcription-coupled nucleotide excision repair (TC-NER) efficiently eliminates transcription-blocking lesions (TBLs), thereby safeguarding accurate transcription, preserving correct cellular function and counte...
ORGANISM(S): Homo sapiens (Human) 
2024-10-16 | PXD051720 | Pride
Ubiquitylation Pol ii Transcription-coupled nucleotide excision repair Stk19 Tfiih 
GenomicsSTK19 accelerates the clearance of lesion-stalled RNAPII to facilitate transcription-coupled DNA repair
STK19 accelerates the clearance of lesion-stalled RNAPII to facilitate transcription-coupled DNA repair
PRJNA1105870 | ENA
UnknownEvidence That STK19 Is Not an NRAS-dependent Melanoma Driver.
Not available
S-EPMC7298618 | biostudies-literature
GenomicsSTK19 accelerates the clearance of lesion-stalled RNAPII to facilitate transcription-coupled DNA repair
STK19 accelerates the clearance of lesion-stalled RNAPII to facilitate transcription-coupled DNA repair
PRJNA1138739 | ENA
GenomicsSTK19 accelerates the clearance of lesion-stalled RNAPII to facilitate transcription-coupled DNA repair [BrU-seq]
STK19 accelerates the clearance of lesion-stalled RNAPII to facilitate transcription-coupled DNA repair [BrU-seq]
PRJNA1105856 | ENA
UnknownSTK19 positions TFIIH for cell-free transcription-coupled DNA repair.
Not available
S-EPMC11645862 | biostudies-literature
UnknownSTK19 positions TFIIH for cell-free transcription-coupled DNA repair.
Not available
S-EPMC11291053 | biostudies-literature
OtherSTK19 accelerates the clearance of lesion-stalled RNAPII to facilitate transcription-coupled DNA repair
Transcription-coupled DNA repair (TCR) removes bulky DNA lesions impeding RNA polymerase II (RNAPII) transcription. Recent studies have outlined the stepwise assembly of TCR factors CSB, CSA, UVSSA, and TFIIH around lesion-stalled RNAPII. However, the mechanism and factors required for the transitio...
ORGANISM(S): Homo sapiens 
2024-11-26 | GSE272790 | GEO
OtherSTK19 accelerates the clearance of lesion-stalled RNAPII to facilitate transcription-coupled DNA repair
Transcription-coupled DNA repair (TCR) removes bulky DNA lesions impeding RNA polymerase II (RNAPII) transcription. Recent studies have outlined the stepwise assembly of TCR factors CSB, CSA, UVSSA, and TFIIH around lesion-stalled RNAPII. However, the mechanism and factors required for the transitio...
ORGANISM(S): Homo sapiens 
2024-09-02 | GSE266085 | GEO
UnknownMutations found in cancer patients compromise DNA binding of the winged helix protein STK19.
Not available
S-EPMC11189558 | biostudies-literature
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