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TranscriptomicsGene regulation in hematopoietic cells by Pcgf1 in a Runx1 null background
The transcription factor Runx1 is essential for the establishment of definitive hematopoiesis during embryonic development. In adult blood homeostasis, Runx1 plays a pivotal role in the maturation of lymphocytes and megakaryocytes. Furthermore, Runx1 is required for the regulation of hematopoietic s...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-33280 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bone marrow cells with a conditional Mef2c knockout or a Mef2c rescue
Acute myelogenous leukemia (AML) is driven by leukemic stem cells (LSC) generated by mutations that confer (or maintain) self-renewal potential coupled to an aberrant differentiation program. Using retroviral mutagenesis, we identified genes that generate LSC in collaboration with genetic disruption...
ORGANISM(S): Mus musculus 
2009-08-15 | E-GEOD-17231 | biostudies-arrayexpress
TranscriptomicsGene expression analysis to identify Runx1 target genes in GMP
Disrupting mutations of the RUNX1 gene are found in 10% of patients with myelodysplasia (MDS) and 30% of patients with acute myeloid leukemia (AML). Previous studies have revealed an increase in hematopoietic stem cells (HSCs) and multipotent progenitor (MPP) cells in conditional Runx1-knockout (KO)...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81177 | biostudies-arrayexpress
TranscriptomicsGene expression analysis to identify Mef2c/d target genes in B-cell progenitors
The sequential activation of distinct developmental gene networks governs the ultimate identity of a cell, but the mechanisms by which downstream programs are activated are incompletely understood. The preB-cell receptor (preBCR) is an important checkpoint of B-cell development and essential for a p...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-73561 | biostudies-arrayexpress
TranscriptomicsGene expression analysis to identify Runx1 target genes in GMP, MEP and Gene expression signature of Runx1Î?/Î? lin- sca- kit+ CD105- CD16/32+ CD150+ (XMP) progenitors
We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of mouse embryonic...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81181 | biostudies-arrayexpress
GenomicsGenome-wide mapping of Mef2c-bound sites in early B-cell progenitors
The sequential activation of distinct developmental gene networks governs the ultimate identity of a cell, but the mechanisms by which downstream programs are activated are incompletely understood. The preB-cell receptor (preBCR) is an important checkpoint of B-cell development and essential for a p...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-73453 | biostudies-arrayexpress
GenomicsGenome-wide Runx1 binding sites in early hematopoietic progenitors (FDCP1)
We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of mouse embryonic...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81179 | biostudies-arrayexpress
TranscriptomicsGene expression analysis to identify Klf2 target genes in B-cell progenitors [+Klf2]
The sequential activation of distinct developmental gene networks governs the ultimate identity of a cell, but the mechanisms by which downstream programs are activated are incompletely understood. The preB-cell receptor (preBCR) is an important checkpoint of B-cell development and essential for a p...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-73559 | biostudies-arrayexpress
TranscriptomicsGene expression analysis to identify Klf2 target genes in B-cell progenitors [Klf2_KO]
The sequential activation of distinct developmental gene networks governs the ultimate identity of a cell, but the mechanisms by which downstream programs are activated are incompletely understood. The preB-cell receptor (preBCR) is an important checkpoint of B-cell development and essential for a p...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-73560 | biostudies-arrayexpress
TranscriptomicsGene expression analysis to identify target genes activated after preBCR signaling
The sequential activation of distinct developmental gene networks governs the ultimate identity of a cell, but the mechanisms by which downstream programs are activated are incompletely understood. The preB-cell receptor (preBCR) is an important checkpoint of B-cell development and essential for a p...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-73562 | biostudies-arrayexpress
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