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TranscriptomicsRoquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.
The degradation of TNFM-NM-1 mRNA is critical for restricting TNFM-NM-1 synthesis and involves a constitutive decay element (CDE) in the 3M-bM-^@M-^Y untranslated region of the mRNA. We demonstrate that the active CDE is a stem-loop RNA motif that is recognized by the RNA-binding protein Roquin. Dee...
ORGANISM(S): Mus musculus 
2013-05-15 | E-GEOD-44775 | biostudies-arrayexpress
ProteomicsNascent Ribo-Seq measures ribosomal loading time and reveals kinetic impact on ribosome density
mRNAs are generally assumed to be loaded instantly with ribosomes upon entry into the cytoplasm. To measure ribosome density on nascent mRNA, we developed nascent Ribo-Seq (nRibo-Seq) by combining Ribo-Seq with progressive 4-thiouridine labelling. In mouse macrophages, we experimentally determined, ...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-22 | PXD026828 | Pride
Ribo-seq Translatome Nascent peptides 
UnknownStress-induced nuclear speckle reorganization is linked to activation of immediate early gene splicing.
Not available
S-EPMC10641589 | biostudies-literature
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