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TranscriptomicsThe glycogen scaffolding protein PTG coordinately regulates glycogen and lipid storage
Glycogen and lipid are major storage forms of energy that are tightly regulated by hormones and metabolic signals. Here, we evaluate the role of the glycogenic scaffolding protein PTG/R5 in energy homeostasis. We demonstrate that feeding mice a high-fat diet (HFD) increases hepatic glycogen, corresp...
ORGANISM(S): Mus musculus 
2014-06-13 | E-GEOD-45319 | biostudies-arrayexpress
UnknownLife Cycle Assessment of Closed-Loop Pumped Storage Hydropower in the United States.
Not available
S-EPMC10448748 | biostudies-literature
ProteomicsPeptide profile of the storage proteins of chickpea, wheat, soybean analyzed with LC-MS/MS
Aiming to reduce food spoilage, the present study developed novel highly active food-grade preservatives affecting a wide range of bacteria. For this purpose, storage proteins were extracted from food plants. After enzymatic hydrolysis by the digestive protease chymotrypsin, the peptide profiles wer...
ORGANISM(S): Cicer arietinum (Chickpea) (Garbanzo) Glycine max Triticum aestivum (Wheat) 
2021-01-11 | PXD019257 | Pride
Storage proteins Chickpea Chymotryptic digestion Soybean Wheat Lc-ms/ms 
TranscriptomicsThe RPB2 flap loop of human RNA polymerase II is dispensable for transcription initiation and elongation.
Deletion of the flap loop in the Rp2 subunit of human RNAPII did not alter the ability of human RNAPII to initiate transcription or elongate the initiated transcripts in vivo and in vitro, and was also dispensable for elongation factor-mediated enhancement and inhibition of transcript elongation in ...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-29734 | biostudies-arrayexpress
ProteomicsProteomic Profiles of Human Arterioles Isolated from Fresh Adipose Tissue or Following Overnight Storage
Arterioles are key determinants of the total peripheral vascular resistance, which, in turn, is a key determinant of arterial blood pressure. However, the amount of protein available from one isolated human arteriole may be less than 5µg, making proteomic analysis challenging. In addition, obtaining...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD044454 | Pride
Arterioles Tmt labeled mass spectrometry Booster channel Overnight storage Proteomics 
TranscriptomicsYY1 Controls Em-3â??RR DNA Loop Formation and Immunoglobulin Heavy Chain Class Switch Recombination.
Activation of splenic B cells induces formation of a 220kb DNA loop between Em and 3â??RR enhancers in the immunoglobulin heavy chain locus (IgH). This DNA loop has been proposed to be necessary for the crucial immune diversification mechanism of IgH class switch recombination, but the factors that...
ORGANISM(S): Mus musculus 
2016-08-06 | E-GEOD-85259 | biostudies-arrayexpress
ProteomicsMulticolumn Nanoflow Liquid Chromatography System with Accelerated Offline Gradient Generation for Robust and Sensitive Single-Cell Proteome Profiling
Peptide separations that combine high sensitivity, robustness, peak capacity and throughput are essential for extending bottom-up proteomics to smaller samples including single cells. To this end, we have developed a multicolumn nanoLC system with accelerated offline gradient generation. One binary ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049248 | Pride
High throughput Proteomics Lc-ms Storage loop Single cell proteomics Multiple columns 
ProteomicsNuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity
The transcriptional co-activator and acetyltransferase p300 is required for fundamental cellular processes, including differentiation and growth. Here, we report that p300 forms phase separated condensates in the cell nucleus. The phase separation ability of p300 is regulated by autoacetylation and ...
ORGANISM(S): Homo sapiens (Human) 
2021-08-26 | PXD026898 | Pride
P300 nuclear condensates hat activity 
UnknownModulation of DNA loop lifetimes by the free energy of loop formation.
Not available
S-EPMC4267329 | biostudies-literature
ProteomicsUntargeted proteomics profiling of liver and plasma in fed and fasted Glycogen Storage Disease type Ia (GSD Ia) mice: towards pathophysiological mechanisms and potential protein biomarkers for hepatic GSD Ia
Glycogen storage disease type Ia (GSD Ia) is a rare autosomal recessive disorder caused by a deficiency in glucose 6-phosphatase-α (G6PC). Patients primarily suffer from failure to thrive, hepatomegaly and severe fasting intolerance, biochemically characterized by hypoketotic and hyperlipidemia. Sin...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD054398 | Pride
Proteomics Plasma Liver Gsd ia Biomarkers 
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