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UnknownRegulation of USP28 deubiquitinating activity by SUMO conjugation.
Not available
S-EPMC4263883 | biostudies-literature
ProteomicsMolecular basis of Tousled-Like-Kinase 2 (TLK2) activation – LC-MS/MS-based analysis of HEK293-expressed TLK2 phosphorylation state
In this study on human Tousled-Like-Kinase 2 (TLK2) mass spectrometry-based analysis was applied as part of a molecular characterization of TLK2 in the aim to increase the understanding of the mode of activation of this protein. Specifically, different TLK2 constructs were expressed analyzed to gene...
ORGANISM(S): Homo sapiens (Human) 
2018-09-04 | PXD009095 | Pride
Human Tlk2 Hek293 Phosphosites 
MetabolomicsPositional Enrichment by Proton Analysis (PEPA): a One-Dimensional 1H-NMR Approach for 13C Stable Isotope Tracer Studies in Metabolomics
A novel metabolomics approach for NMR-based stable isotope tracer studies called PEPA is presented, and its performance validated using human cancer cells. PEPA detects the position of carbon label in isotopically enriched metabolites and quantifies fractional enrichment by indirect determination of...
2017-02-23 | MTBLS247 | MetaboLights
ProteomicsTLK2-associated intellectual disability: report of six novel cases and molecular characterization of p.(Asp551Gly) and p.(Ser617Leu) variants
Introduction The Tousled-Like Kinases 1 and 2 (TLK1 and TLK2) are involved in many fun-damental processes, including DNA replication, cell cycle checkpoint recovery and chromatin remodelling. Mutations in TLK2 were recently associated with “Mental Retardation Autoso-mal Dominant 57” (MRD57), a neuro...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD019450 | Pride
Tousled like kinases Tlk2 Autism spectrum disorder Proximal interac-tome Comet assay Bioid Intellectual disability Chromatin condensation Mrd57 
UnknownRisk factors for catastrophic costs associated with tuberculosis in rural South Africa.
Not available
S-EPMC6755915 | biostudies-literature
UnknownPositional Enrichment by Proton Analysis (PEPA): A One-Dimensional 1 H-NMR Approach for 13 C Stable Isotope Tracer Studies in Metabolomics.
Not available
S-EPMC5363230 | biostudies-literature
ProteomicsSIRT1 regulates DNA damage signaling through PP4 phosphatase complex
The Sirtuin family of NAD+-dependent enzymes play an important role in the maintenance of genome stability upon stress. Several mammalian Sirtuins have been linked directly or indirectly to the regulation of DNA damage during replication through Homologous recombination (HR). The role of one of them...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-06-15 | PXD036905 | Pride
Label free proteomics Pp4 phosphatase complex H2ax Sirt1 Dna damage response 
UnknownSIRT1 regulates DNA damage signaling through the PP4 phosphatase complex.
Not available
S-EPMC10359614 | biostudies-literature
UnknownDefects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice.
Not available
S-EPMC6503982 | biostudies-literature
UnknownA recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome.
Not available
S-EPMC3757051 | biostudies-literature
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