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ProteomicsMolecular basis of Tousled-Like-Kinase 2 (TLK2) activation – LC-MS/MS-based analysis of TLK2 phosphorylation state
In this study on human Tousled-Like-Kinase 2 (TLK2) mass spectrometry-based analysis was applied as part of a molecular characterization of TLK2 in the aim to increase the understanding of the mode of activation of this protein. Specifically, different TLK2 constructs were analyzed to generate a “ph...
ORGANISM(S): Homo sapiens (Human) 
2018-10-23 | PXD007675 | Pride
Human Lc-msms Tlk2 
ProteomicsMolecular basis of Tousled-Like-Kinase 2 (TLK2) activation – LC-MS/MS-based analysis of HEK293-expressed TLK2 phosphorylation state
In this study on human Tousled-Like-Kinase 2 (TLK2) mass spectrometry-based analysis was applied as part of a molecular characterization of TLK2 in the aim to increase the understanding of the mode of activation of this protein. Specifically, different TLK2 constructs were expressed analyzed to gene...
ORGANISM(S): Homo sapiens (Human) 
2018-09-04 | PXD009095 | Pride
Human Tlk2 Hek293 Phosphosites 
ProteomicsAutophosphorylation of Tousled-like kinases (TLK1 and TLK2) regulates recruitment to damaged chromatin via PCNA interaction (Phospho-TMT analysis of TLK1)
PhosphoTMT experiment on HEK293T cells transiently transfected with either SFB-TLK1, SFB-TLK2, or siRNAs targeting TLK1, TLK2, or TLK1 and TLK2. Data represents 4 biological replicates.
ORGANISM(S): Homo sapiens (Human) 
2025-01-02 | PXD047966 | Pride
Phosphoproteomics Tandem affinity purification Tousled-like kinases Phospho-tmt 
ProteomicsTLK2-associated intellectual disability: report of six novel cases and molecular characterization of p.(Asp551Gly) and p.(Ser617Leu) variants
Introduction The Tousled-Like Kinases 1 and 2 (TLK1 and TLK2) are involved in many fun-damental processes, including DNA replication, cell cycle checkpoint recovery and chromatin remodelling. Mutations in TLK2 were recently associated with “Mental Retardation Autoso-mal Dominant 57” (MRD57), a neuro...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD019450 | Pride
Tousled like kinases Tlk2 Autism spectrum disorder Proximal interac-tome Comet assay Bioid Intellectual disability Chromatin condensation Mrd57 
ProteomicsThe circadian E3 ligase complex SCFFBXL3+CRY targets TLK2
We recently demonstrated that the circadian clock component CRY2 is an essential cofactor in the SCFFBXL3-mediated ubiquitination of c-MYC. Because our demonstration that CRY2 recruits phosphorylated substrates to SCFFBXL3 was unexpected, we investigated the scope of this role by searching for addit...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD009522 | Pride
Circadian clock 
UnknownTLK2 promotes progression of hepatocellular carcinoma through Wnt/β-catenin signaling.
Not available
S-EPMC11319953 | biostudies-literature
UnknownAmplification of TLK2 Induces Genomic Instability via Impairing the G2-M Checkpoint.
Not available
S-EPMC5065758 | biostudies-literature
UnknownThe circadian E3 ligase complex SCFFBXL3+CRY targets TLK2.
Not available
S-EPMC6336870 | biostudies-literature
UnknownA TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption.
Not available
S-EPMC11986041 | biostudies-literature
UnknownChromatin looping-based CRISPR screen identifies TLK2 as chromatin loop formation regulator in cancer stemness plasticity.
Not available
S-EPMC12540834 | biostudies-literature
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