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MetabolomicsMaHPIC Experiment E03 - Quantitative Metabolomics of Macaca mulatta infected with Plasmodium coatneyi Hackeri strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute, recrudescent, and chronic infections
MaHPIC Experimental Description:
Malaria-naive male rhesus macaques (Macaca mulatta), approximately four years of age, were inoculated intravenously with salivary gland sporozoites produced and isolated at the Centers for Disease Control and Prevention from multiple Anopheles
2018-09-05 | MTBLS691 | MetaboLights
MetabolomicsMaHPIC Experiment 30: Quantitative Metabolomics from the pilot experiment for Macaca mulatta infected with Plasmodium knowlesi Malayan strain sporozoites to produce and integrate clinical, hematological, parasitological, omics, telemetric and histopathological measures of acute primary infection
Telemetry devices (DSI, model L11) with blood pressure sensors and electrocardiogram (ECG) leads were surgically implanted in two malaria-naive male rhesus macaques (Macaca mulatta), approximately three years of age. After a resting period of two weeks, physiological data that include activit...
2019-01-11 | MTBLS821 | MetaboLights
TranscriptomicsIntra- and inter-individual genetic differences in gene expression
Each expressed gene was tested for differential expression in three mouse tissues (Brain, Kidney, Liver) in a direct comparison of SJL/J vs. C57BL/6J Keywords: direct comparison, multiple tissues Whole RNA from a pool of 5 SJL/J mice was compared to a pool of RNA from C57BL/6J mice with three techni...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-8358 | biostudies-arrayexpress
TranscriptomicsDietary folate depletion and repletion in A/J and C57BL/6J mice
Defects in homocysteine and folate metabolism are associated with increased risks for neural tube and congenital heart defects, cardiovascular disease and stroke, cancers, and neurodegeneration. In many but not all cases, dietary supplementation with folate significantly reduces the severity and in...
ORGANISM(S): Mus musculus 
2008-08-27 | E-GEOD-9242 | biostudies-arrayexpress
OtherMaHPIC Experiment 23: Lipidomics from Macaca mulatta infected with Plasmodium cynomolgi B strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute primary infection and relapses.

Malaria-naive male rhesus macaques (Macaca mulatta), approximately four years of age, were inoculated intravenously with salivary gland sporozoites produced and isolated at the Centers for Disease Control and Prevention from multiple Anopheles species (An. dirus, An. gambi...

ORGANISM(S): Macaca Mulatta Plasmodium Cynomolgi Strain B 
2017-03-16 | MSV000080637 | MassIVE
TranscriptomicsTranscription profiling of liver from wistar and kyoto rats exposed to orotic acid to investigate fatty liver disease
Although fatty liver disease is caused by a number of toxicological insults and the metabolic syndrome, the exact mechanisms by which many of these pathophysiological stimulii induce fatty liver are unknown. The rapid and profound steatosis caused by orotic acid, resulting from an impairment in the ...
ORGANISM(S): Rattus norvegicus 
2009-03-11 | E-BIID-1 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling for wild-type, single and double mutants for Nuclear Factor YA1 (nf-ya1) and hypernodulation phenotype (har1) mutants in roots of Lotus japonicus
Acting in a partially redundant manner, NF-Ys were shown previously to regulate bacterial infection, including selection of a superior rhizobial strain, and to participate in mediating nodule structure formation. However, the exact mechanism(s) by which these transcriptional factors exert their symb...
ORGANISM(S): Lotus japonicus 
2017-05-03 | E-MTAB-4970 | biostudies-arrayexpress
ProteomicsProteomics of Mouse Syngeneic Models
The cell line-derived xenografts and patient derived xenografts have limited use in cancer immunotherapy evaluation because an immune compromised host is required for xenotransplantation. Syngeneic mouse models are derived by transplanting established mouse cell lines or tumor tissues to strain matc...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-03 | PXD011885 | Pride
Mouse sygeneic Immuno-oncology Tumor 
OtherMaHPIC Experiment 04: Lipidomics from Macaca mulatta infected with Plasmodium cynomolgi B strain to produce and integrate clinical, hematological, parasitological, and omics measures of acute primary infection and relapses

Malaria-naive male rhesus macaques (Macaca mulatta), approximately three years of age, were inoculated intravenously with salivary gland sporozoites produced and isolated at the Centers for Disease Control and Prevention from multiple Anopheles species (An. dirus, An. gambiae...

ORGANISM(S): Macaca Mulatta Plasmodium Cynomolgi Strain B 
2017-03-08 | MSV000080610 | MassIVE
TranscriptomicsNon-genotoxic Hepatocarcinogens
There is no accurate and well-validated short-term test for non-genotoxic carcinogens, necessitating an expensive two year rodent bioassay before a risk assessment can begin. We have developed a short-term in vivo rat assay that predicts whether non-genotoxic chemicals are likely to induce hepatic t...
ORGANISM(S): Rattus norvegicus 
2007-06-22 | E-GEOD-8251 | biostudies-arrayexpress
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