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TranscriptomicsExpression data from stimulated or unstimulated human CD4+ T cells incubated with edelfosine
The cytotoxic drug edelfosine is a synthetic analog of 2-lysophosphatidylcholine. Edelfosine is incorporated by highly proliferating cells, e.g. activated immune cells. It is unknown if the described mechanisms for edelfosine action attained by in vitro approaches exclusively contribute to the obser...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-44392 | biostudies-arrayexpress
TranscriptomicsMammary carcinomas in WAP-SV40 transgenic mice
This SuperSeries is composed of the following subset Series: GSE29117: Mammary carcinomas in WAP-SV40 transgenic mice [gene expression] GSE31097: Mammary carcinomas in WAP-SV40 transgenic mice [aCGH] GSE33038: Involuted normal mammary gland in WAP-SV40 transgenic mice [gene expression] Refer to indi...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-31212 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of T-lymphoblastic leukemia of childhood [gene expression]
The purpose of this study was the principal investigation and frequency of RTK expression in primary T-ALLs. Primary initial T-ALLs were assessed regarding their transcriptome-wide expression profiles and screend for prominent RTK expression. Naive primary T-ALL samples were evaluated with regard t...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-42038 | biostudies-arrayexpress
TranscriptomicsMammary carcinomas in WAP-SV40 transgenic mice [aCGH]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-31097 | biostudies-arrayexpress
TranscriptomicsExpression data of two human cancer cell lines cultivated in 2-dimensional (2D) vs. 3-dimensional (3D) cell culture
3D cultivation of cells lead to changes in morphology of the cells. This is likely to explain the higher radioresistance of cells growing in 3D compared to cells growing in 2D cell culture. Whole genome gene expression is performed to determine genes involved in changes of cell moroholgy and radiore...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-17347 | biostudies-arrayexpress
TranscriptomicsMammary carcinomas in WAP-SV40 transgenic mice [gene expression]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-29117 | biostudies-arrayexpress
TranscriptomicsInvoluted normal mammary gland in WAP-SV40 transgenic mice [gene expression]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-33038 | biostudies-arrayexpress
TranscriptomicsExpression data from articular and growth plate cartilage
The aim of the current study was to identify molecular markers for articular cartilage that can be used for the quality control of tissue engineered cartilage. Therefore a genom-wide expression analysis was performed using RNA isolated from articular and growth plate cartilage, both extracted from t...
ORGANISM(S): Sus scrofa 
2011-07-28 | E-GEOD-23492 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of NCAM-deficient mouse brain
Analysis of brains of mice lacking the neural cell adhesion molecule NCAM (Ncam-/-) in comparison to wild-type mice of same age and genetic background (Ncam+/+). NCAM-deficient mice exhibit deficits in long-term potentiation and spatial learning, as well as increased intermale aggression. We perform...
ORGANISM(S): Mus musculus 
2009-12-01 | E-GEOD-16647 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary lung adenocarcinomas
We have investigated whether the early dissemination of tumor cells into bone marrow is associated with a specific molecular pattern in primary lung cancer Experiment Overall Design: two groups of primary lung adenocarcinomas were compared differentiating in the metastatic potential
ORGANISM(S): Homo sapiens 
2009-03-14 | E-GEOD-10799 | biostudies-arrayexpress
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