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MetabolomicsPKA regulates stress granule maturation to allow timely recovery after prolonged starvation
Cells have evolved multiple strategies to survive environmental stress conditions. This includes the formation of membrane-less cytoplasmic ribonucleoprotein structures called stress granules that sequester and protect mRNAs encoding many housekeeping genes. Stress granules are not static biomolecul...
2026-06-16 | MTBLS13923 | MetaboLights
TranscriptomicsThe Small Molecule ISRIB Reverses the Effects of eIF2α Phosphorylation on Translation and Stress Granule Assembly
We recently identified ISRIB as a potent inhibitor of the integrated stress response (ISR). ISRIB renders cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (10.7554/eLife.00498). Here we show by genome-wide in vivo ribosome profiling that translation o...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-65778 | biostudies-arrayexpress
TranscriptomicsAPEX-seq of time course of P-body and Stress Granule transcriptomes during stress
The regulation of cytosolic mRNAs during and after stress occurs through the formation of distinct membraneless organelles. However, the compositional and functional dynamics of these structures throughout the stress response remain poorly understood. Here, we combine APEX2-mediated proximity labell...
ORGANISM(S): Homo sapiens 
2025-12-01 | E-MTAB-14668 | biostudies-arrayexpress
ProteomicsProximity-dependent biotinylation detects association between stress granule associated proteins and SARS coronavirus nonstructural protein 1
Severe acute respiratory syndrome coronavirus (SARS-CoV and SARS-CoV-2) nonstructural protein 1 (nsp1) is a critical viral protein that suppresses host gene expression by blocking the assembly of the ribosome on host messenger RNAs (mRNA). Using proximity-dependent biotinylation assay followed by pr...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025980 | Pride
Nsp1 Stress granule Sars-cov Sars-cov-2 Bioid2 
TranscriptomicsECT2 and AURKB Modulate Formation of Stress Granules Containing Transcripts from Diverse Cellular Pathways in Astrocytoma Cells
Stress granules are small RNA-protein granules that modify the translational landscape during cellular stress to promote survival. The RhoGTPase RhoA is implicated in the formation of RNA stress granules. Our data demonstrate that the cytokinetic proteins ECT2 and AurkB are localized to stress gran...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-76814 | biostudies-arrayexpress
ProteomicsReduced insulin/IGF-1 signaling restores the dynamic properties of key stress granule proteins during aging
Low complexity “prion-like” domains in key RNA-binding proteins (RBPs) mediate the reversible assembly of RNA granules. Individual RBPs harboring these domains have been linked to specific neurodegenerative diseases. Although their aggregation in neurodegeneration has been extensively characterized,...
ORGANISM(S): Caenorhabditis elegans 
2017-01-16 | PXD003451 | Pride
Caenorhabditis elegans Itraq Quantification Aging Insulin Aggregation 
ProteomicsThe small molecule lipoamide modulates stress granule condensation with beneficial outcomes for familial amyotrophic lateral sclerosis models
Neurodegenerative diseases like amyotrophic lateral sclerosis are often associated with mutations in proteins which can form stress granules by liquid-liquid phase separation (LLPS). Formation of these condensate phases requires a complex molecular grammar for protein-protein interactions which, whe...
ORGANISM(S): Homo sapiens (Human) 
2025-05-09 | PXD039670 | Pride
Stress granule Small molecules Amyotrophic lateral sclerosis Molecular condensates Liquid-liquid phase separation 
TranscriptomicsDysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue
During cell stress, the transcription and translation of immediate early genes are prioritized, while most other mRNAs are stored away in stress granules or degraded in P-bodies. TIA-1 is an mRNA binding protein that needs to translocate from the nucleus to seed the formation of stress granules in t...
ORGANISM(S): Mus musculus 
2014-10-06 | E-GEOD-54418 | biostudies-arrayexpress
TranscriptomicsA Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. During infection, Toxoplasma actively remodels the transcriptome of its hosting cells with profound and coupled impact on the host immune response. ...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-38782 | biostudies-arrayexpress
TranscriptomicsAnalysis of P-body (Dcp1) and Stress Granule (Pbp1) RNA content
Non-membrane-bound compartments such as mRNA processing bodies (PBs) and stress granules (SGs) play important roles in the regulation of gene expression following environmental stresses. Here we perform RIP-seq to determine the RNA interactors of Dcp1 (PB marker) and Pbp1 (SG marker) before and afte...
ORGANISM(S): Saccharomyces cerevisiae 
2021-09-30 | E-MTAB-9096 | biostudies-arrayexpress
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