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TranscriptomicsintDCs versus LCs
miRNA profiling of CD34+ derived, in vitro-generated Langerhans cells (LCs) and interstitial-type dendritic cells (intDCs). Epidermal Langerhans cells (LCs) form a network of dendritic cells (DCs) in basal/suprabasal layers of the skin and are characterized by a unique phenotype (CD207+ CD1abright C...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20215 | biostudies-arrayexpress
TranscriptomicsSystems Biology Analysis of Tenofovir 1% Gel in a Phase I Rectal Microbicide Trial
In MTN-007, a phase 1, randomized, double-blinded rectal microbicide trial, we used systems genomics/proteomics to determine the effect of tenofovir 1% gel, nonoxynol-9 2% gel, placebo gel or no treatment on rectal biopsies taken at baseline, after one application or after seven daily applications (...
ORGANISM(S): Homo sapiens 
2015-02-23 | E-GEOD-57025 | biostudies-arrayexpress
TranscriptomicsEx vivo effects of Tenofovir on four vaginal epithelial cell lines
In MTN-007, a phase 1, randomized, double-blinded rectal microbicide trial, we used systems genomics/proteomics to determine the effect of tenofovir 1% gel, nonoxynol-9 2% gel, placebo gel or no treatment on rectal biopsies taken at baseline, after one application or after seven daily applications (...
ORGANISM(S): Homo sapiens 
2015-02-23 | E-GEOD-57026 | biostudies-arrayexpress
UnknownSurveillance Study of Influenza Occurrence and Immunity in a Wisconsin Cohort During the 2009 Pandemic.
Not available
S-EPMC5510460 | biostudies-literature
TranscriptomicsNext generation sequencing of small RNAs isolated from exosomes in human semen
Preparation of exosomes isolated from semen contain a substantial amount of RNA, mostly from 20 to 100 nucleotides in length. We sequenced separately 20-40 and 40-100 nucleotide fractions of RNA from exosomes isolated from semenal fluid from six healthy donors. We found various classes of small non...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-56076 | biostudies-arrayexpress
GenomicsChIPseq profile of RNA polymerase (pol II), the p65 subunit of NFkB, STAT1 and STAT2 in bone marrow derived macrophages after treatment with IFNb, heat-killed Listeria monocytogenes (hkL), or both.
Using ChIP-Seq analysis we define genes induced in macrophages through synergistic transcriptional activation by NFkB and the IFNb-activated transcription factor ISGF3.
ORGANISM(S): Mus musculus 
2015-06-15 | E-MTAB-2972 | biostudies-arrayexpress
TranscriptomicsMonocytic cell differentiation from band-stage neutrophils under inflammatory conditions
During inflammation, neutrophils are rapidly mobilized from the bone marrow storage pool into peripheral blood to subsequently enter lesional sites where most of them rapidly undergo apoptosis. Monocytes constitute a second wave of inflammatory immigrates giving rise to long-lived macrophages and de...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-58920 | biostudies-arrayexpress
TranscriptomicsComparison of the expression profiles of wild-type (WT), Tyk2-deficient (Tyk2-/-) and kinase-inactive Tyk2 mutant (Tyk2K923E) NK cells
Define the impact of Tyk2 and Tyk2K923E on the transcriptome of NK cells Tyrosine kinase 2 (TYK2) is a Janus kinase (JAK) that is crucially involved in inflammation, carcinogenesis and defense against infection. The cytotoxic activity of natural killer (NK) cells in TYK2-deficient (Tyk2-/- ) mice is...
ORGANISM(S): Mus musculus 
2015-04-28 | E-GEOD-68294 | biostudies-arrayexpress
GenomicsA gene regulatory network for neural induction
During early vertebrate development, signals from a special region of the embryo, the organizer, can re-direct the fate of non-neural ectoderm cells to form a complete, patterned nervous system. This is called neural induction and has generally been imagined as a single signaling event, causing a sw...
ORGANISM(S): Gallus gallus 
2023-03-14 | E-MTAB-10424 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E. coli BL21(DE3) to analyze the cellular response to high level expression of recombinant human super-oxide-dismutase (SOD)
This transcription profiling time course experiment was conducted in order to analyze the cellular response of E. coli BL21(DE3) to high level expression of recombinant human super-oxide-dismutase (SOD) on the transcriptional level. Three biological replicates were generated by using a carbon limite...
ORGANISM(S): Escherichia coli 
2011-09-30 | E-MARS-19 | biostudies-arrayexpress
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