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TranscriptomicsHsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis with no increased bleeding risk
Atrial fibrillation (AF) is a major risk factor for cardioembolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern particularly when antiplatelet treatment is simultaneously administer...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-66724 | biostudies-arrayexpress
ProteomicsMolecular characterization of the brain peri-infarct region after post-stroke MANF administration
Shotgun proteomics analysis of brain peri-infarct region from rats subjected to ischemic stroke and treated with AAV-MANF or a control AAV-eGFP, compared to each other and to rats subjected to a sham operation.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2019-05-28 | MSV000083869 | MassIVE
TranscriptomicsThe age and genomic integrity of neurons after cortical stroke in humans
It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA-rearrangements in the human neocortex. We show here that neither is the case, using immunohistochemistry, transcriptome-, genome- and ploidy-analyses, and determination of nuclear bomb test-derived 14C-concentration in ...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-56267 | biostudies-arrayexpress
TranscriptomicsIdentification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke
Because most human stroke victims are elderly, studies of experimental stroke in the aged rather than the young rat model may be optimal for identifying clinically relevant cellular responses, as well for pinpointing beneficial interventions. We employed the Affymetrix platform to analyze the whole-...
ORGANISM(S): Rattus norvegicus 
2014-04-22 | E-GEOD-55260 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of stroke-susceptible and asymptomatic human carotid plaques
A microarray analysis of advanced human atherosclerotic carotid artery plaques (equal or over 70% stenosis, NASCET criteria) from radiologically confirmed ipsilateral stroke patients (stroke-susceptible plaques, n=12) compared with carotid plaques collected from clinically asymptomatic patients with...
ORGANISM(S): Homo sapiens 
2011-12-30 | E-MEXP-2257 | biostudies-arrayexpress
TranscriptomicsmicroRNAs involved in regulating embolic stroke recovery following spontaneous reperfusion [miRNA]
To date, miRNA expression studies on cerebral ischemia in both human and animal models have focused mainly on acute phase of ischemic stroke. In this study, we present the roles played by microRNAs in the spontaneous recovery phases in cerebral ischemia using rodent stroke models. In this study pres...
ORGANISM(S): Rattus norvegicus 
2013-12-09 | E-GEOD-46266 | biostudies-arrayexpress
TranscriptomicsmicroRNAs involved in regulating embolic stroke recovery following spontaneous reperfusion [mRNA]
To date, miRNA and mRNA expression studies on cerebral ischemia in both human and animal models have focused mainly on acute phase of ischemic stroke. In this study, we present the roles played by microRNAs in the spontaneous recovery phases in cerebral ischemia using rodent stroke models. In this s...
ORGANISM(S): Rattus norvegicus 
2013-12-09 | E-GEOD-46267 | biostudies-arrayexpress
TranscriptomicsEffects of Hsp72 on astrocyte activation following stroke in the mouse
Astrogliosis is a hallmark of the response to brain ischemia, comprised of changes in gene expression and morphology. Hsp72 protects from cerebral ischemia, and although several mechanisms of protection have been investigated, effects on astrocyte activation are unknown. To identify potential mecha...
ORGANISM(S): Mus musculus 
2013-01-11 | E-GEOD-28731 | biostudies-arrayexpress
TranscriptomicsSprouting transcriptome in cortical neurons: aged
Selective isolation of total RNA and then whole genome expression analysis of sprouting neurons in peri-infarct cortex of the adult rat after stroke, compared to adjacent neurons that have not sprouted a new connection, in young adult (2 months) and aged (2 years) animals. Two different fluorescent ...
ORGANISM(S): Rattus norvegicus 
2010-11-15 | E-GEOD-24441 | biostudies-arrayexpress
TranscriptomicsSprouting transcriptome in cortical neurons: young
Selective isolation of total RNA and then whole genome expression analysis of sprouting neurons in peri-infarct cortex of the adult rat after stroke, compared to adjacent neurons that have not sprouted a new connection, in young adult (2 months) and aged (2 years) animals. Two different fluorescent ...
ORGANISM(S): Rattus norvegicus 
2010-11-15 | E-GEOD-24440 | biostudies-arrayexpress
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