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MetabolomicsGut Microbiota Regulates Serum Metabolites in Mice with Nonalcoholic Fatty Liver Disease via Gut Metabolites: Mechanisms Involving Branched-Chain Amino Acids and Unsaturated Fatty Acids

In recent years, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease globally. Studies indicate that the gut-liver axis plays an important role in the occurrence and development of this disease. Our previous studies showed that the gut microbiota and gut meta...

2025-07-02 | MTBLS12668 | MetaboLights
MetabolomicsDietary Bacillus coagulans supplementation improves liver health and modulates hepatic metabolic profiles in juvenile fourfinger threadfin (Eleutheronema tetradactylum)

Dietary supplementation with probiotics has emerged as a promising strategy to enhance the health and productivity of farmed fish. This study investigated the effects of dietary Bacillus coagulans on the hepatic morphology, oxidative status, and metabolic profiles of juvenile fourfinger threadfin...

2026-07-23 | MTBLS15102 | MetaboLights
MetabolomicsMultiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health

In order to explore opportunities for personalized and predictive health care, we collected serial clinical measurements, health surveys and multiomics profiles (genomics, proteomics, autoantibodies, metabolomics and gut microbiome) from 96 individuals. The participants underwent data-driven heal...

2021-09-02 | MTBLS2187 | MetaboLights
MetabolomicsMulti-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats
Health effects of pesticides are not always accurately detected using the current battery of regulatory toxicity tests. We compared standard histopathology and serum biochemistry measures and multi-omics analyses in a subchronic toxicity test of a mixture of six pesticides frequently detected in foo...
2020-11-19 | MTBLS138 | MetaboLights
ProteomicsPregnancy alters fatty acid metabolism, glucose regulation, and detoxification of the liver in synchrony with biomechanical property changes
Pregnancy places a metabolic burden on the body including the liver, which is responsible for ensuring adequate nutrition for the maternal and fetal systems. To gain a better understanding of liver adaptation, this study investigates metabolic shifts occurring in livers of pregnant rats. Metabolic c...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-10-22 | PXD050758 | Pride
Pregnancy Metabolic Structural liver changes 
MetabolomicsSaline pasture improve meat quality in Qinghai Tibetan sheep through changes in the rumen microbiota

Introduction: This study aimed to investigate the effects of natural forage from different regions (saline-alkali and non-saline-alkali areas) on the rumen microbiota, muscle metabolites, and meat quality of Tibetan sheep. 

Methods: Targeted and non-targeted metabolomics were used to c...

2025-07-19 | MTBLS12748 | MetaboLights
TranscriptomicsTranscription profiling time series of orotic acid induced fatty liver disease in Rattus norvegicus
A time course of orotic acid induced fatty liver disease. Kyoto and Wistar strain rats were exposed to orotic acid for days 1, 3 and 14. Controls are also included.
ORGANISM(S): Rattus norvegicus 
2007-10-11 | E-GEOD-665 | biostudies-arrayexpress
TranscriptomicsTumor Liver vs Normal Liver: ChIP-chip and RNA expression
There is widespread interest in efficient characterization of differences between tumor and normal samples. Here, we demonstrate an effective methodology for genome-scale characterization of tumors. Using matched normal and tumor samples from liver cancer patients, as well as non-cancer-related nor...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10842 | biostudies-arrayexpress
TranscriptomicsProtease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta
During chronic liver disease, tissue remodeling leads to dramatic changes and accumulation of matrix components. Matrix metalloproteases and their inhibitors have been involved in the regulation of matrix degradation. However, the role of other proteases remains incompletely defined. We undertook a ...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-24667 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers at different time points after partial hepatectomy and at different time points post conception to elucidate gene expression similarities between regenerating and developing liver.
Normal adult liver is uniquely capable of renewal; and repair after injury. Whether this response; represents simple hyperplasia of various liver elements; or requires recapitulation of the genetic program of; the developing liver is not known. To study these possibilities, we examined transcription...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6998 | biostudies-arrayexpress
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