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ProteomicsA structure-based modelling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia
Abstract Mutations activating RAS/RAF/MEK/ERK signaling are associated with poor outcome in acute myeloid leukemia (AML), but therapeutic targeting of this pathway is challenging. Here, we employ a structure-based, dynamic RAS pathway model to successfully predict RAF inhibitor (RAFi) combinations ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-24 | PXD063606 | Pride
Drug combinations Ras-mutant acute myeloid leukemia. Structure-based modelling 
UnknownA primer on multiscale modelling of infectious disease systems.
Not available
S-EPMC6326222 | biostudies-literature
UnknownProtein structure modelling and evaluation based on a 4-distance description of side-chain interactions.
Not available
S-EPMC2912888 | biostudies-literature
UnknownComputational investigation of potent inhibitors against SARS-CoV-2 2'-O-methyltransferase (nsp16): Structure-based pharmacophore modeling, molecular docking, molecular dynamics simulations and binding free energy calculations.
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S-EPMC9385381 | biostudies-literature
UnknownDiscovery of new potent lysine specific histone demythelase-1 inhibitors (LSD-1) using structure based and ligand based molecular modelling and machine learning.
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S-EPMC9751883 | biostudies-literature
UnknownModelling the 3D Structure of PEDOT:PSS Supramolecular Assembly in Aqueous Dispersion Based on SAXS with Synchrotron Light
Not available
S-EPMC10033293 | biostudies-literature
UnknownA structure-based modelling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia.
Not available
S-EPMC12247986 | biostudies-literature
UnknownTemplate-Based Modelling of the Structure of Fungal Effector Proteins.
Not available
S-EPMC11043172 | biostudies-literature
UnknownModelling opinion dynamics under the impact of influencer and media strategies.
Not available
S-EPMC10632524 | biostudies-literature
TranscriptomicsGenome-Wide Specificity of DNA-Binding, Gene Regulation, and Chromatin Remodeling by TALE- and CRISPR/Cas9-Based Transcription Factors
Synthetic DNA-binding proteins have found broad application in gene therapies and as tools for interrogating biology. Engineered proteins based on the CRISPR/Cas9 and TALE systems have been used to alter genomic DNA sequences, control transcription of endogenous genes, and modify epigenetic states. ...
ORGANISM(S): Homo sapiens 
2015-05-27 | E-GEOD-68341 | biostudies-arrayexpress
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