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TranscriptomicsThe Effect of the Leptin Receptor Q223R Polymorphism on the Host Transcriptome Following Infection with E. histolytica.
Resistance to amebiasis is associated with a polymorphism in the leptin receptor. Previous studies demonstrated that humans with the ancestral Q223 leptin receptor allele were nearly four times less likely to be infected with Entamoeba histolytica than those carrying the mutant R223 allele. We hypot...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-43372 | biostudies-arrayexpress
TranscriptomicsDevelopmental transitions of Coxiella burnetii grown in axenic media
Coxiella burnetii undergoes a biphasic developmental cycle within its host cell that generates morphologically and physiologically distinct large cell variants (LCV) and small cell variants (SCV). During the lag phase of the C. burnetii growth cycle, non-replicating SCV differentiate into replicati...
ORGANISM(S): Coxiella burnetii 
2013-12-02 | E-GEOD-51135 | biostudies-arrayexpress
TranscriptomicsThe antimicrobial peptide-sensing system aps of Staphylococcus aureus
Staphylococcus aureus is a leading cause of hospital-associated infections. In addition, highly virulent strains of methicillin-resistant S. aureus (MRSA) are currently spreading outside health care settings. Survival in the human host is largely defined by the ability of S. aureus to resist mechani...
ORGANISM(S): Staphylococcus aureus 
2008-04-06 | E-GEOD-8400 | biostudies-arrayexpress
TranscriptomicsDevelopmental stage specific metabolic and transcriptional activity of chlamydial elementary bodies and reticulate bodies in an axenic medium
Chlamydia trachomatis is a significant human pathogen yet their obligate intracellular nature severe restrictions upon research. Chlamydiae undergo a complex developmental cycle characterized by an infectious cell type known as the elementary body (EB) and an intracellular active replicative form ...
ORGANISM(S): Chlamydia trachomatis 
2012-11-20 | E-GEOD-39530 | biostudies-arrayexpress
TranscriptomicsPreadaptation of Yersinia pestis to resist mammalian innate immunity during transit through the flea vector
Yersinia pestis, the agent of plague, is transmitted to mammals by infected fleas. Y. pestis exhibits a distinct life stage in the flea, where it grows in the form of a cohesive biofilm that promotes transmission. After transmission, the temperature shift to 37°C induces many known virulence factors...
ORGANISM(S): Yersinia pestis 
2010-04-06 | E-GEOD-16493 | biostudies-arrayexpress
TranscriptomicsA Gram-positive three-component antimicrobial peptide-sensing system
To survive during colonization or infection of the human body, microorganisms must defeat antimicrobial peptides, which represent a key component of innate host defense in phagocytes and on epithelia. However, is not known how the clinically important group of Gram-positive bacteria sense antimicrob...
ORGANISM(S): Staphylococcus epidermidis 
2010-05-26 | E-GEOD-7163 | biostudies-arrayexpress
TranscriptomicsPlasmid-free Chlamydia trachomatis elicit lowered inflammation, delayed apoptosis, and reduced chemoattractant expression in HeLa cells compared to plasmid-containing wild type
Chlamydia trachomatis serovariants are responsible for either Trachoma, the leading cause of infectious blindness or sexually transmitted disease, wherein the endocervix is the most frequently infected site in women. Disease caused by Chlamydia typically involves chronic inflammation and scarring. ...
ORGANISM(S): Homo sapiens 
2014-11-25 | E-GEOD-56168 | biostudies-arrayexpress
TranscriptomicsHost cell-free growth of the Q fever bacterium Coxiella burnetii
The inability to propagate obligate intracellular pathogens under axenic (host cell-free) culture conditions imposes severe experimental constraints that have negatively impacted progress in understanding pathogen virulence and disease mechanisms. Coxiella burnetii, the causative agent of human Q (Q...
ORGANISM(S): Coxiella burnetii 
2010-06-20 | E-GEOD-13338 | biostudies-arrayexpress
TranscriptomicsIntracellular proliferation and virulence gene expression of Salmonella are influenced by pre-invasion growth conditions
Salmonella invasion of non-phagocytic cells is a dynamic process that requires the translocation of effector proteins into host cells by a type III secretion system (T3SS1) encoded on Salmonella pathogenicity island 1 (SPI1). The signals involved in T3SS1 induction in vivo are not known, but SPI1-in...
ORGANISM(S): Salmonella typhimurium SL1344 
2010-04-19 | E-GEOD-13343 | biostudies-arrayexpress
TranscriptomicsNIH/NIAID On the resistance of Staphylococcus aureus to neutrophil microbicides
Staphylococcus aureus strain MW2 was exposed to the following neutrophil microbicides, hydrogen peroxide (H2O2), hypochlorous acid (HOCl) and azurophilic granule proteins. At the indicated time points, bacterial cultures were centrifuged and bacteria were lysed with RLT buffer (Qiagen) using a Fast...
ORGANISM(S): Staphylococcus aureus 
2010-05-26 | E-GEOD-6716 | biostudies-arrayexpress
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