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ProteomicsGenesis and regulation of C-terminal cyclic imides from protein damage
C-Terminal cyclic imides are post-translational modifications (PTMs) that can arise from spontaneous intramolecular cleavage of asparagine or glutamine residues resulting in a form of irreversible protein damage. These protein damage events are recognized and removed by the E3 ligase substrate adapt...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD054016 | Pride
Protein cleavage Cyclic imide Cereblon Protein damage Post-translational modifications Deamidation 
TranscriptomicsDifferential production of Type I IFN determines the reciprocal levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages
Pattern recognition receptors (PRR) detect microbial products and induce cytokines which shape the immunological response. Interleukin-12 (IL-12), tumor necrosis factor alpha (TNF-α) and IL-1β are proinflammatory cytokines which can be essential for resistance against infection, but if produced at...
ORGANISM(S): Mus musculus 
2016-09-07 | E-GEOD-79809 | biostudies-arrayexpress
TranscriptomicsGene expression data for worker honey bees experimentally exposed to a dual infection with Deformed wing virus and Nosema ceranae.
Bees from 3 unrelated colonies were injected with 1ul PBS extract containing 10^9 genome equivalent of Deformed wIng virus (DWV) and/or fed 10µl sucrose solution containing 10^5 fresh Nosema ceranae spores. Control bees were injected and fed with an equivalent DWV- and Nosema-free extract respectiv...
ORGANISM(S): Apis mellifera 
2017-03-08 | E-MTAB-5508 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling analysis by microarray comparing the isogenic wild-type strain Bacillus thuringiensis 407 with a markerless cdgF deletion mutant was performed with exponentially growing cells in planktonic culture.
The transcriptional global profiles of the wild-type strain Bacillus thuringiensis 407 and a cdgF deletion mutant were compared after 1.5 hours of growth in an planktonic culture to analyze the effect of deletion of cdgF, which is involved in c-di-GMP signaling, on the global expression profile of B...
ORGANISM(S): Bacillus thuringiensis Bt407 
2019-07-30 | E-MTAB-8092 | biostudies-arrayexpress
UnknownRapamycin versus methotrexate in early diffuse systemic sclerosis: results from a randomized, single-blind pilot study.
Not available
S-EPMC2841149 | biostudies-literature
TranscriptomicsComparison of gene expression in wild-type Drosophila testes with tbrd-1 mutant testes
Gene expression is tightly linked to histone acetylation on lysine residues that can be recognized by bromodomains. The testis-specific bromodomain protein tBRD-1 is essential for male fertility and might act as a co-factor of testis-specifc TAFs. Here, we perform microarray analyses and demonstrate...
ORGANISM(S): Drosophila melanogaster 
2014-08-08 | E-GEOD-52511 | biostudies-arrayexpress
ProteomicsRegulation of electrogenic Na+/HCO3- cotransporter 1 (NBCe1) in mouse cortical astrocytes and its dependence on m-TOR mediated phosphorylation of Ser245.
Astrocytes are pivotal responders to alterations of extracellular pH, primarily by regulation of their “master” acid-base transporter, the membrane-bound electrogenic Na+/bicarbonate cotransporter 1 (NBCe1). Here, we describe an mTOR-dependent and NBCe1-mediated astroglial response to extracellular ...
ORGANISM(S): Mus Musculus 
2022-01-12 | PXD024529 | panorama
UnknownAssociation between Neonatal Whole Blood Iron Content and Cytokines, Adipokines, and Other Immune Response Proteins.
Not available
S-EPMC6470999 | biostudies-literature
TranscriptomicsMYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma.
MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive effects in MYCN-amplified neuroblastoma cells. In profiling studies, histone deacetylase (HDAC) inhibitor treatment most strongly induced miR-183...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-44538 | biostudies-arrayexpress
TranscriptomicsFree fatty acids and TNF-alpha in HepG2 cell culture
The regulation of complex cellular activities in palmitate treated HepG2 cells, and the ensuing cytotoxic phenotype, involves cooperative interactions between genes. While previous approaches have largely focused on identifying individual target genes, elucidating interacting genes has thus far rema...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-26885 | biostudies-arrayexpress
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