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TranscriptomicsV(D)J TCR single cell sequencing of mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis
Mucosal pinch biopsies from ascending, transverse, descending colon and rectum were obtained from ulcerative colitis (UC) and primary sclerosing cholangitis concomitant with colitis (PSC-UC) patients during routine endoscopies and subjected to 5' single-cell RNA sequencing with V(D)J TCR analysis
ORGANISM(S): Homo sapiens 
2026-06-17 | E-MTAB-14899 | biostudies-arrayexpress
TranscriptomicsV(D)J BCR single cell sequencing of mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis
Mucosal pinch biopsies from ascending, transverse, descending colon and rectum were obtained from ulcerative colitis (UC) and primary sclerosing cholangitis concomitant with colitis (PSC-UC) patients during routine endoscopies and subjected to 5' single-cell RNA sequencing with V(D)J BCR analysis
ORGANISM(S): Homo sapiens 
2026-06-17 | E-MTAB-14901 | biostudies-arrayexpress
MetabolomicsAnalysis of colorectal adenocarcinoma tissue samples by DESI mass spectrometry imaging
Ex vivo colorectal adenocarcinoma samples were analysed by desorption electrospray ionisation using an Orbitrap mass spectrometer. The samples were analysed in negative mode over the m/z range 600-1000. Some of the samples presented in this dataset were analysed as part of [1]. The study makes avail...
2016-04-28 | MTBLS289 | MetaboLights
ProteomicsTankyrase modulates insulin sensitivity in skeletal muscle cells by regulating stability of GLUT4 vesicle proteins
Tankyrase1 and 2, members of the poly(ADP-ribose) polymerase family, play a role in multiple biological processes including Wnt signalling and glucose uptake. However, their role in glucose uptake remains elusive, particularly in skeletal muscle cells. Treatment of differentiated L6 myotubes with th...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-04-17 | PXD007182 | Pride
Gsv Tankyrase Skeletal muscle 
ProteomicsVolpatti_Myopathy_P124_Lumos_VS8
This dataset consists of 9 raw MS files, acquired on Orbitrap Fusion Lumos Tribrid mass spectrometer operated in Data Dependent Acquisition mode. Cells and lysates were generated by Jonathan Volpatti. Sample processing and mass spectrometry acquisition was performed by Cassandra Wong. Data analysis...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-12 | MSV000089872 | MassIVE
UnknownFailure to detect M. avium subspecies paratuberculosis in Johne's disease using a proprietary fluorescent in situ hybridization assay.
Not available
S-EPMC6054717 | biostudies-literature
UnknownCrohn's disease: failure of a proprietary fluorescent in situ hybridization assay to detect M. avium subspecies paratuberculosis in archived frozen intestine from patients with Crohn's disease.
Not available
S-EPMC7038517 | biostudies-literature
GenomicsGenome-wide Analysis Reveals Conserved and Divergent Features of Notch1/RBPJ Binding in Human and Murine T Lymphoblastic Leukemia Cells
Notch1 regulates gene expression by associating with the DNA-binding factor RBPJ and is oncogenic in murine and human T cell progenitors. Using ChIP-Seq, we find that in human and murine T-LL genomes Notch1 binds preferentially to promoters, to RBPJ binding sites, and near imputed ZNF143, Ets and Ru...
ORGANISM(S): Mus musculus 
2011-07-06 | E-GEOD-29600 | biostudies-arrayexpress
ProteomicsGlobal redox proteome and phosphoproteome analysis reveals novel mode of Akt regulation
A major knowledge gap in cell signalling is defining the crosstalk between multiple types of post-translational modification (PTM). Here, we take a multi-omic approach (redox proteome, phosphoproteome and total proteome) to delineate signalling networks in adipocytes modulated by reactive oxygen spe...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-12-10 | PXD011525 | Pride
Phosphoproteome Akt Crosstalk Redox proteome 
TranscriptomicsPrimary human erythroid progenitor cells HDAC1 and HDAC2 shRNA knockdown samples
Gene expression profiling was performed on primary human erythroid progenitor cells expressing a control shRNA (luciferase), two different HDAC1 shRNAs, and two different HDAC2 shRNAs. The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year ...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-22366 | biostudies-arrayexpress
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