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MetabolomicsMetabolite Correlation Networks Reveal Complex Phenotypes of Adaptation-Driving Mutations

Living organisms are organized into hierarchical levels of increasing complexity. As mutational effects propagate through these levels, multiple phenotypes are produced. However, identifying which phenotypes influence fitness and drive selection remains a key challenge in understanding genotype-p...

2026-08-10 | MTBLS14569 | MetaboLights
TranscriptomicsComparative analysis of gene expression in two yeast species and their interspecific hybrid
We compared the genome-wide expression profiles of two yeast species (S. cerevisiae and S. paradoxus) using a two-species microarray that contain species-specific probes and can thus measure the expression levels of the two species simultaneosly. In Addition, we used the array to measure expression ...
ORGANISM(S): Saccharomyces paradoxus 
2010-06-20 | E-GEOD-14708 | biostudies-arrayexpress
UnknownC-terminal domain dimerization in yeast Hsp90 is moderately modulated by the other domains.
Not available
S-EPMC10808039 | biostudies-literature
TranscriptomicsThe Conserved Polarity Factor PodJ1 Impacts Multiple Cell Envelope-Associated Functions in Sinorhizobium meliloti
Although diminutive in size, bacteria possess highly diverse and spatially confined cellular structures. Two related alpha-proteobacteria, Sinorhizobium meliloti and Caulobacter crescentus, serve as models for investigating the genetic basis of morphologic variations. S. meliloti, a symbiont of le...
ORGANISM(S): Sinorhizobium meliloti 
2012-08-09 | E-GEOD-31325 | biostudies-arrayexpress
TranscriptomicsRNAPolII ChIP to find differences between third instar salivary glands of WT and SuUR
ChIP was performed to identify regions of gDNA bound by RNA polymerase II in third instar salivary glands of Drosophila WT and SuUR mutants. This demonstrated that RNAPolII does not localize to regions that are under-replicated in SuUR mutant third instar salivary glands. Comparison of RNAPolII ChI...
ORGANISM(S): Drosophila melanogaster 
2011-10-17 | E-GEOD-31896 | biostudies-arrayexpress
TranscriptomicsInduction of ER stress in HCT116 colon cancer cells
To investigate the role of p53 and DICER in the induction of ER stress, wildtype, p53 knockout or DICER mutant HCT116 colon cancer cells were treated with the ER stress inducers tunicamycin or brefeldin A for 24 hours. Microarray analysis was used to determine changes in gene expression associated w...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-63252 | biostudies-arrayexpress
TranscriptomicsIdentification of direct T-box target genes in the developing zebrafish mesoderm
The zebrafish genes spadetail (spt) and no tail (ntl) encode T-box transcription factors that are important for early mesoderm development. Although much has been done to characterize these genes, the identity and location of target regulatory elements remain largely unknown. Here, we survey the gen...
ORGANISM(S): Danio rerio 
2010-05-19 | E-GEOD-12857 | biostudies-arrayexpress
TranscriptomicsAn in vivo screen identifies compounds that disrupt heterochromatin integrity
Heterochromatin plays a key role in gene repression, maintaining genome integrity and chromosome segregation. Fission yeast, Schizosaccharomyces pombe, utilizes conserved components to direct heterochromatin formation using siRNA generated by RNA interference (RNAi) to guide a histone H3 lysine 9 me...
ORGANISM(S): Schizosaccharomyces pombe 
2014-12-17 | E-GEOD-57207 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung from wildtype and glucocorticoid recepter knockouts to investigate investigate the role of glucocorticoids in fetal lung development
The aim of this experiment is to investigate the role of glucocorticoids in fetal lung development in more detail.
ORGANISM(S): Mus musculus 
2007-05-31 | E-MEXP-861 | biostudies-arrayexpress
TranscriptomicsmRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum
Schizophrenia (SCZ) is a common, disabling mental illness with high heritability but complex, poorly understood genetic etiology. As the first phase of a genomic convergence analysis of SCZ, we generated 16.7 billion nucleotides of short read, shotgun sequences of cDNA from post-mortem cerebellar c...
ORGANISM(S): Homo sapiens 
2009-08-29 | E-GEOD-12297 | biostudies-arrayexpress
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