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GenomicsGenome-wide map of lysine specific demethylase 1 (LSD1) in mouse embryonic stem cells.
We report the identification of LSD1 binding genomic regions in mouse embryonic stem cells (ESC) by high throughput sequencing. By obtaining over 10 million 36 bp reads of sequence from each chromatin immunoprecipitated DNA, we generated genome-wide maps for LSD1 and histone H3 dimethylated on lysin...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-18515 | biostudies-arrayexpress
TranscriptomicsLEOPARD Syndrome iPS, BJ iPS and Fibroblasts
Expression data from LEOPARD Syndrome-iPS clones, BJ-iPS cells and parental Fibroblasts 9 samples in total are analyzed. Among 22011 genes in expression data, there are 3657 genes with at least 2 fold expression change between the average of the three fibroblast lines versus all of the iPS lines/HE...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20473 | biostudies-arrayexpress
GenomicsWdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network
The embryonic stem (ES) cell transcriptional and epigenetic networks are critical for the maintenance of ES cell self-renewal. However, it remains unclear whether components of these networks functionally interact and if so, what factors mediate such interactions. Here we show that WD-repeat protein...
ORGANISM(S): Mus musculus 
2011-04-08 | E-GEOD-22934 | biostudies-arrayexpress
TranscriptomicsKRAS-Dependent Sorting of miRNAs and other small RNAs to secreted vesicles
Although long thought to act cell autonomously, mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. We have previously shown that mutant KRAS induces EGFR-ligand trafficking to exosomes and drastically alters exosomal protein contents,...
ORGANISM(S): Homo sapiens 
2015-08-28 | E-GEOD-67004 | biostudies-arrayexpress
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