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TranscriptomicsGlobal DNA methylation profiling of CD4+ T cells from patients with systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic-relapsing autoimmune disease of incompletely understood etiology. Recent evidence strongly supports an epigenetic contribution to the pathogenesis of lupus. To understand the extent and nature of dysregulated DNA methylation in lupus T cells, we perfor...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-27895 | biostudies-arrayexpress
TranscriptomicsISR target genes in the liver of either LFD and HFD-treated Alb::GC mice and AP20187-treated TTR::Fv2E-PERK mice
The molecular mechanisms linking the stress of unfolded proteins in the endoplasmic reticulum (ER stress) to glucose intolerance in obese animals are poorly understood. In this study enforced expression of a translation initiation 2alpha (eIF2a)-specific phosphatase, GADD34, was used to selectively ...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-11210 | biostudies-arrayexpress
TranscriptomicsISR target genes in the liver of mock-injected and AP20187-treated mice of wildtype and Atf4-/- genotype
The molecular mechanisms linking the stress of unfolded proteins in the endoplasmic reticulum (ER stress) to glucose intolerance in obese animals are poorly understood. In this study enforced expression of a translation initiation 2α (eIF2α)-specific phosphatase, GADD34, was used to selectively comp...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-11116 | biostudies-arrayexpress
GenomicsPersistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions
The androgen receptor (AR) is a ligand-inducible transcription factor that mediates androgen action in target tissues. Upon ligand binding, the AR binds to thousands of genomic loci and activates a cell-type specific gene program. Prostate cancer growth and progression depend on androgen-induced AR ...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-40050 | biostudies-arrayexpress
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