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Blood transcriptional signatures may predate clinical diagnosis and detect subclinical incipient tuberculosis (TB) disease. To validate such blood signatures, close contacts of TB patients were recruited from multiple TB clinics in London. Close contacts of active TB were defined as individuals with...
ORGANISM(S): Homo sapiens 
Identification of blood transcriptional biomarkers linked to different phases of tuberculosis. The discovery of a transcriptional signature that distinguishes subclinical TB from incipient TB at baseline could lead to tuberculosis interventions that combat the tuberculosis epidemic in the context of...
ORGANISM(S): Homo sapiens 
2023-01-10 | GSE193777 | GEO
Host blood-based biosignatures for subclinical TB: a prospective study of household contacts of adult pulmonary TB index cases in Southern India.
Individuals exposed to Mtb can experience a range of outcomes: early bacterial clearance, latent Mtb infection (LTBI), asymptomatic TB (bacteriologically confirmed or not), or symptomatic TB (bacteriologically confirmed or clinically diagnosed). Current tools cannot reliably predict or distinguish ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2026-03-03 | PXD068329 | Pride
Individuals exposed to Mtb can experience a range of outcomes: early bacterial clearance, latent Mtb infection (LTBI), asymptomatic TB (bacteriologically confirmed or not), or symptomatic TB (bacteriologically confirmed or clinically diagnosed). Current tools cannot reliably predict or distinguish ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2026-03-03 | PXD068195 | Pride
Individuals exposed to Mtb can experience a range of outcomes: early bacterial clearance, latent Mtb infection (LTBI), asymptomatic TB (bacteriologically confirmed or not), or symptomatic TB (bacteriologically confirmed or clinically diagnosed). Current tools cannot reliably predict or distinguish ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2026-03-03 | PXD068197 | Pride
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