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ProteomicsRasGRP1 is a Causal Factor in the Development of L-DOPA-induced dyskinesia in Parkinson Disease
The therapeutic benefits of L–3,4–dihydroxyphenylalanine (L-DOPA) in Parkinson’s disease (PD) patients severely diminishes with the onset of L-DOPA-induced dyskinesia (LID), a debilitating motor side effect. LID is mainly due to altered dopaminergic signaling in the striatum, a brain region that con...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-22 | PXD017434 | Pride
Dyskinesia Parkinson disease Rasgrp1 
ProteomicsMutant huntingtin stalls ribosomes and represses protein synthesis independent of fragile X mental retardation protein
Ribosomes translocate one codon at a time in mRNA during protein synthesis, but the regulators of ribosome translocation and their impact on neurodegenerative disease remain poorly understood. Here, we show that huntingtin (Htt) and its poly-Q expanded form, mHtt, a cause of Huntington disease (HD),...
ORGANISM(S): Homo sapiens (Human) 
2021-04-06 | PXD017115 | Pride
Ribosome Huntingtin Protein synthesis Fragile x 
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