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TranscriptomicsGenome-wide gene expression analysis in primary ciliary dyskinesia patients
We performed whole genome gene expression profiling in bronchial biopsies from PCD patients. We used the Quality Threshold clustering algorithm to identify groups of genes that revealed highly correlated RNA expression patterns in the biopsies. The largest cluster contained 372 genes and was signifi...
ORGANISM(S): Homo sapiens 
2015-02-24 | E-GEOD-25186 | biostudies-arrayexpress
TranscriptomicsMolecular Adaptations of Striatal Spiny Projection Neurons During Levodopa-Induced Dyskinesia
L-3,4-dihydroxyphenylalanine (levodopa) treatment is the major pharmacotherapy for Parkinson's disease. However, almost all patients receiving levodopa eventually develop debilitating involuntary movements (dyskinesia). While it is known that striatal spiny projection neurons (SPNs) are involved in ...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-55096 | biostudies-arrayexpress
GenomicsDynamic DNA Methylation Regulates Levodopa-Induced Dyskinesia
Levodopa-induced dyskinesia (LID) is a persistent behavioral sensitization that develops after repeated levodopa (L-DOPA) exposure in Parkinson disease (PD) patients. we used reduced representation bisulfite sequencing to determine the methylation status of cytosines genome wide at base pair resolu...
ORGANISM(S): Rattus norvegicus 
2016-06-16 | E-GEOD-83385 | biostudies-arrayexpress
GenomicsPrimary ciliary dyskinesia in Cocker spaniels in Australia
Primary ciliary dyskinesia in Cocker spaniels in Australia
PRJEB113647 | ENA
UnknownClinical care for primary ciliary dyskinesia: current challenges and future directions.
Not available
S-EPMC9489029 | biostudies-literature
GenomicsESGI Identification of novel genes and mechanisms leading to Primary Ciliary Dyskinesia
Approximately 80% of clinically clearly diagnosed patients suffering from primary ciliary dyskinesia (PCD) cannot be assigned to a specific gene defect. Despite extensive research on PCD and despite the increasing number of PCD genes and knowledge about their sites of action as e.g structural compon...
EGAS00001000523 | EGA
GenomicsRiluzole administration to rats with levodopa-induced dyskinesia analyzed by RRBS
Riluzole administration to rats with levodopa-induced dyskinesia analyzed by RRBS
PRJNA734572 | ENA
ProteomicsRasGRP1 is a Causal Factor in the Development of L-DOPA-induced dyskinesia in Parkinson Disease
The therapeutic benefits of L–3,4–dihydroxyphenylalanine (L-DOPA) in Parkinson’s disease (PD) patients severely diminishes with the onset of L-DOPA-induced dyskinesia (LID), a debilitating motor side effect. LID is mainly due to altered dopaminergic signaling in the striatum, a brain region that con...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-22 | PXD017434 | Pride
Dyskinesia Parkinson disease Rasgrp1 
GenomicsPrimary ciliary dyskinesia without obvious electron microscopy defects
Primary ciliary dyskinesia without obvious electron microscopy defects
PRJNA635175 | ENA
GenomicsPrimary ciliary dyskinesia without obvious electron microscopy defects
Primary ciliary dyskinesia without obvious electron microscopy defects
PRJNA635176 | ENA
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