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ProteomicsRasGRP1 is a Causal Factor in the Development of L-DOPA-induced dyskinesia in Parkinson Disease
The therapeutic benefits of L–3,4–dihydroxyphenylalanine (L-DOPA) in Parkinson’s disease (PD) patients severely diminishes with the onset of L-DOPA-induced dyskinesia (LID), a debilitating motor side effect. LID is mainly due to altered dopaminergic signaling in the striatum, a brain region that con...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-22 | PXD017434 | Pride
Dyskinesia Parkinson disease Rasgrp1 
GenomicsRasGRP1 is a critical epithelial gatekeeper of the intestinal tuft cell program
RasGRP1 is a critical epithelial gatekeeper of the intestinal tuft cell program
PRJNA1378934 | ENA
UnknownRASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics.
Not available
S-EPMC6400263 | biostudies-literature
UnknownDysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity.
Not available
S-EPMC7894479 | biostudies-literature
TranscriptomicsRasGRP1 is a critical epithelial gatekeeper of the intestinal tuft cell program
To characterize the intestinal tuft cell lineage and assess how RasGRP1 influences tuft cell production, we isolated tuft cells from the small intestine of wild-type and Rasgrp1-/- mice and profiled them using single-cell RNA sequencing.
ORGANISM(S): Mus musculus 
2026-08-31 | GSE313226 | GEO
UnknownIncreased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis.
Not available
S-EPMC7655557 | biostudies-literature
UnknownRasGRP1 induces autophagy and transformation-associated changes in primary human keratinocytes.
Not available
S-EPMC7569238 | biostudies-literature
UnknownRasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth.
Not available
S-EPMC9669001 | biostudies-literature
UnknownRasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.
Not available
S-EPMC4652934 | biostudies-literature
UnknownLoss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.
Not available
S-EPMC5801500 | biostudies-literature
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