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ProteomicsInfection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis
Transglutaminase 2 (TG2) is a ubiquitous enzyme with transamidating activity. We report here that the expression and activity of TG2 are enhanced in cells infected with the obligate intracellular bacteria Chlamydia trachomatis. Genetic or pharmacological inhibition of TG2 activity impair bacterial d...
ORGANISM(S): Homo sapiens (Human) Chlamydia trachomatis E/C599 
2020-02-25 | PXD017117 | Pride
Chlamydia Hexosamine biosynthesis O-glcnacylation Gfpt Transglutaminase 2 
ProteomicsMetabolic imprint of an intracellular pathogen drives histone hypermethylation and tunes the host transcriptional response to infection
Chlamydia trachomatis, an obligate intracellular bacterium, highjacks metabolites from the host cell to sustain its own growth. We provide evidence of global hypermethylation of the host proteome, including histones, during the late stages of infection and that histone hypermethylation is the result...
ORGANISM(S): Homo sapiens (Human) Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) 
2026-10-05 | PXD051857 | Pride
Intracellular pathogen Innate immunity Metabolites Histone demethylase Hypermethylation Chlamydia trachomatis Epigenetic 
UnknownInfection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells
Not available
S-SCDT-EMBOJ-2019-102166 | biostudies-other
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