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Microarray analysis has been useful for identifying the targets of many transcription factors. However, gene expression changes in response to transcription factor perturbation reveal both direct transcriptional targets and secondary gene regulation. By integrating RNA interference, gene expression ...
ORGANISM(S): Homo sapiens 
Transcriptome profile in SULF2 knockdown pancreatic tumor cells
Investigating the role of GLI1 in SULF2-potentiated liver tumorigenesis
The expression of the extracellular sulfatase, SULF2, has been strongly associated with increased hepatocellular carcinoma (HCC) tumor growth and poorer patient survival. However, to date, the molecular mechanisms underlying this phenomenon remain in part unclear. To address this issue, we developed...
ORGANISM(S): Mus musculus 
2019-10-25 | GSE139374 | GEO
We constructed the SULF2 knockdown cell lines and its controls in CFPAC-1 cells using CRISPR-cas9 system, followed by transcriptome sequencing.
ORGANISM(S): Homo sapiens 
2022-03-02 | GSE197531 | GEO
In this study, we characterized the substrate preferences of human HSulf2 using HS oligosaccharides with various lengths and sulfation degrees from several naturally occurring HS sources by applying liquid chromatography mass spectrometry based glycomics methods.
ORGANISM(S): Bos taurus (Bovine) 
2014-07-22 | PXD001157 | Pride
Gene mutations play critical roles during cancer development and progression, and therefore represent targets for precision medicine. Here we recapitulated the pharmacogenomic data to delineate novel candidates for actionable mutations and therapeutic target drugs. As a proof-of-concept, we demonstr...
ORGANISM(S): Homo sapiens 
2018-05-15 | GSE88744 | GEO
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