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ProteomicsImpact of sulfamethoxazole on a riverine microbiome
Freshwater environments such as rivers receive effluent discharges from wastewater treatment plants, representing a potential hotspot for antibiotic resistance genes (ARGs). These effluents also contain low levels of different antimicrobials including biocides and antibiotics such as sulfonamides th...
ORGANISM(S): wastewater metagenome 
2021-07-06 | PXD023822 | Pride
Microflumes Metagenomics Sulfamethoxazole Metaproteomics Warwick-rtp Antimicrobial resistance 
TranscriptomicsWhole genome \"TraDIS-Xpress\" assay to determine gene roles during growth of E. coli in different concentrations of the antibiotics trimethoprim and sulfamethoxazole
To assay every gene in the E. coli genome to identify those that contribute to increased or decreased susceptibility to the antibiotics trimethoprim and sulfamethoxazole. This will help to define more accurately those bacterial cell mechanisms that contribute to these phenomena and provide informat...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2020-10-19 | E-MTAB-9305 | biostudies-arrayexpress
GenomicsTranscriptional Response of Mycobacterium tuberculosis H37Rv to sulfamethoxazole
Transcriptional Response of Mycobacterium tuberculosis H37Rv to sulfamethoxazole
PRJNA484405 | ENA
TranscriptomicsTranscriptional Response of Mycobacterium tuberculosis H37Rv to sulfamethoxazole
To understand the response of M. tuberculosis (MTB) to the drug sulfamethoxazole, we performed transcriptomics on MTB bacilli exposed to the drug.
ORGANISM(S): Mycobacterium tuberculosis 
2018-08-04 | GSE118100 | GEO
TranscriptomicsGene expression changes of Planococcus kocurii O516 in various culture conditions (with or without sulfamethoxazole)
The strain Planococcus kocurii O516 isolated from the marine culture environment was found to be stably and highly effective for the degradation of sulfamethoxazole. We investigated the expression behavior of functional genes related to this degradation ability in P. kocurii O516 under the culture c...
ORGANISM(S): Planococcus kocurii 
2020-08-08 | GSE150668 | GEO
ProteomicsExosomal transport of hepatocyte-derived drug-modified proteins to the immune system
Idiosyncratic drug-induced liver injury (DILI) is a rare, often difficult to predict adverse reaction with complex pathomechanisms. However, it is now evident that certain forms of DILI are immune-mediated and may involve the activation of drug-specific T-cells. Exosomes are cell-derived vesicles th...
ORGANISM(S): Homo sapiens (Human) 
2019-05-14 | PXD010760 | Pride
Exosomes Hepatocytes Immune response Drug-induced liver injury 
TranscriptomicsMeta-transcriptomic analysis of the response of river biofilms to pharmaceutical products using anonymous DNA microarray
Low concentrations of pharmaceutical compounds were shown to induce transcriptional responses in isolated microorganisms, which could have consequences on ecosystem dynamics. In order to test if these transcriptional responses could also be observed in complex river microbial communities, biofilm re...
ORGANISM(S): environmental samples 
2010-07-06 | E-GEOD-20501 | biostudies-arrayexpress
ProteomicsSulfamethoxazole triggers specific microbial activities under aerobic heterotrophic conditions: A metaproteomic approach
The global sanitary crisis derived from antibiotic multi-resistant bacteria entails the need to reduce sulfamethoxazole (SMX) concentrations in wastewater treatment plants (WWTPs). The key microorganisms and the biotransformation mechanisms leading to SMX removal remain incompletely characterized, p...
ORGANISM(S): environmental samples <b-proteobacteria environmental samples <g-proteobacteria 
2022-09-20 | PXD029711 | Pride
Activated sludge  antibiotics  biotransformation  enzymes  micropollutants  proteome  transformation products  wastewater 
GenomicsProfiling the sulfamethoxazole-resistant microbial community along a trophic gradient in the central Adriatic Sea
Profiling the sulfamethoxazole-resistant microbial community along a trophic gradient in the central Adriatic Sea
PRJEB49628 | ENA
GenomicsRe-evaluating trimethoprim-sulfamethoxazole treatment in A. baumannii
Re-evaluating trimethoprim-sulfamethoxazole treatment in A. baumannii
PRJEB105083 | ENA
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