Sort   by:  
 Page size 
TranscriptomicsGenome-wide transcriptome analysis of the dietary chemopreventive phytochemical sulforaphane on normal and prostate cancer cells.
Epidemiological studies provide strong evidence that consumption of cruciferous vegetables, such as broccoli, can significantly reduce the risk of developing cancers. Sulforaphane (SFN), a phytochemical derived from cruciferous vegetables, induces anti-proliferative and pro-apoptotic responses in pr...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-48812 | biostudies-arrayexpress
TranscriptomicsThe effect of sulforaphane on gene expression in FHL124 - a human lens epithelial cell line
The effect of sulforaphane on gene expression in FHL124, a human lens epithelial cell line
ORGANISM(S): Homo sapiens 
2013-06-30 | E-MEXP-3923 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon Caco-2 cells treated with sulforaphane (SF)
Effect of sulforaphane (SF) on human colon caco-2 cells after 24h treatment
ORGANISM(S): Homo sapiens 
2005-07-01 | E-MEXP-170 | biostudies-arrayexpress
ProteomicsCompetition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane’s targets and identify over 500 targets along with their relative affiniti...
ORGANISM(S): Homo sapiens (Human) 
2017-05-24 | PXD006279 | Pride
Sulforaphane  cancer  chemical proteomics 
TranscriptomicsRNA-seq experiment to investigate the effect sulforaphane metabolism in HepG2 cells (human hepatocellular carcinoma cell lines). Cells treated with sulforaphane were compared against untreated cells in three different glucose environments: no glucose, basal and high glucose, to study the transcriptional effect of sulforaphane on liver cells at different metabolic states.
Over the past six years, literature has shown that sulforaphane (SF) can affect a wide range of genes involved in central metabolism, such as glycolysis, pentose phosphate pathway, TCA cycle, lipid biosynthesis and oxidation. In this experiment, RNA sequencing was performed on HepG2 cells in three g...
ORGANISM(S): Homo sapiens 
2024-03-30 | E-MTAB-12851 | biostudies-arrayexpress
TranscriptomicsRNA-seq experiment to investigate the impact of sulforaphane metabolism in HepG2 cells. Cells with NRF2 knockdown treated with sulforaphane were compared to untreated cells with NRF2 knock-down. Similarly, wild type cells treated with sulforaphane were compared to untreated cells.
This study aims to assess whether genes involved in central metabolism induced by Sulforaphane, SF, are mediated through the transcription factor NRF2. A time course RNA-seq experiment was performed, where RNA is extracted after 3, 9, and 24 hours SF treatment. This experiment tests the following hy...
ORGANISM(S): Homo sapiens 
2024-03-30 | E-MTAB-12858 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of prostate gland from wild type and PTEN knock-out mice at different early stage of cancer treated with sulforaphane
Effect on gene expression and alternative splicing of a SF-rich diet on progresssion to prostate cancer using a prostate-specific PTEN knockout mouse model
ORGANISM(S): Mus musculus 
2010-11-01 | E-MEXP-2469 | biostudies-arrayexpress
TranscriptomicsLNCaP cells treated with chemoprevetive agents
BACKGROUND. Prostate cancer is thought to arise as a result of oxidative stresses and induction of antioxidant electrophile defense (phase 2) enzymes has been proposed as a prostate cancer prevention strategy. The isothiocyanate sulforaphane, derived from cruciferous vegetables like broccoli, potent...
ORGANISM(S): Homo sapiens 
2009-01-20 | E-GEOD-14364 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary prostate epithelial and stromal cells exposed to 4-methylsulphinylbutyl and 3-methylsulphinypropyl isothiocyanates
BACKGROUND: Broccoli consumption has been associated with a reduction in risk of prostate cancer. Isothiocyanates (ITC) derived from glucosinolates that accumulate in broccoli are potential dietary compounds that may mediate these health effects. Sulforaphane (SF, 4-methylsulphinylbutyl ITC) accumul...
ORGANISM(S): Homo sapiens 
2009-06-05 | E-MEXP-2034 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human MDS/AML cell line OCI-M2 treated with 5-azacytidine and sulforaphane
The RNA sequencing experiment is part of the study: “Modulating Redox Balance Restores Azacytidine Efficacy in Hypomethylating Agent Resistant Disease.” In the study we generated myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) OCI-M2 cell line that is resistant to hypomethylating therapy b...
ORGANISM(S): Homo sapiens 
2021-07-16 | E-MTAB-10635 | biostudies-arrayexpress
Sort   by:  
 Page size