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TranscriptomicsTiling microarray-based identification of small regulatory RNAs in the group A Streptococcus (GAS)
Small regulatory RNAs (sRNAs) represent a major mechanism of virulence regulation in several pathogens. To date, only three sRNAs have been described in GAS in any detail. To identify whether sRNAs are common within the GAS genome, we created a custom Affymetrix tiling microarray in which all inte...
ORGANISM(S): Streptococcus pyogenes 
2010-05-06 | E-GEOD-17789 | biostudies-arrayexpress
TranscriptomicsA genome-wide analysis of small regulatory RNAs in the human pathogen group A Streptococcus
This SuperSeries is composed of the following subset Series: GSE17767: Transcriptome comparison of Streptococcus pyogenes strain MGAS2221 with that of an isogenic PEL mutant GSE17789: Tiling microarray-based identification of small regulatory RNAs in the group A Streptococcus (GAS) Refer to individu...
ORGANISM(S): Streptococcus pyogenes 
2009-08-25 | E-GEOD-17790 | biostudies-arrayexpress
TranscriptomicsTranscriptome comparison of Streptococcus pyogenes strain MGAS2221 with that of an isogenic PEL mutant
PEL is a small regulatory RNA that is present within the S. pyogenes genome. In some strains of S. pyogenes, the PEL sRNA regulates many of the known virulence factors produced by this pathogen. A genome-wide analysis of PEL-regulated genes had not been performed previously so we analyzed this by ...
ORGANISM(S): Streptococcus pyogenes 
2009-08-25 | E-GEOD-17767 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of covR/S mutant strains of S. pyogenes
Two covR mutant derivatives of parental strain MGAS2221 were recovered from mice experimentally infected with MGAS2221 and shown to differ in terms of the number and concentration of secreted proteins. One of the covR mutant strains had a secretion phenotype identical to a covS mutant strain, while...
ORGANISM(S): Streptococcus pyogenes 
2009-06-05 | E-GEOD-16436 | biostudies-arrayexpress
TranscriptomicsDetermination of transcriptome of SptR in group A Streptococcus during growth in human saliva
The molecular genetic mechanisms used by bacteria to persist in humans are poorly understood. Group A Streptococcus (GAS) causes the majority of bacterial pharyngitis cases in humans and is prone to persistently inhabit the upper respiratory tract. To gain information about how GAS survives in and i...
ORGANISM(S): Streptococcus sp. 'group A' 
2010-05-19 | E-GEOD-16124 | biostudies-arrayexpress
TranscriptomicsTranscriptome comparison of S. pyogenes strains MGAS2221 and 2221ΔFasX following exposure to human plasma
The fasX gene encodes a small regulatory RNA in the group A Streptococcus (GAS). To determine the FasX regulon during GAS exposure to human plasma we compared parental strain MGAS2221 with isogenic fasX mutant strain 2221ΔFasX. Gene expression was analyzed 0, 15, and 60 minutes post-plasma exposur...
ORGANISM(S): Streptococcus pyogenes 
2012-07-31 | E-GEOD-36645 | biostudies-arrayexpress
TranscriptomicsTranscriptome comparison of S. pyogenes strains MGAS2221 and 2221?rivRX
The rivR gene encodes a putative transcriptional regulator, while the rivX gene encodes a putative small regulatory RNA. To determine the RivRX regulon during exponential phase growth in THY broth we compared parental strain MGAS2221 with isogenic rivRX mutant strain 2221?rivRX. GAS strains were gr...
ORGANISM(S): Streptococcus pyogenes 
2012-12-01 | E-GEOD-36646 | biostudies-arrayexpress
TranscriptomicsExpression comparison between MGAS2221 and isogenic spyCEP mutant
Expression analysis was performed to confirm that spyCEP is the only gene differentially regulated between parental strain MGAS2221 and isogenic spyCEP mutant 2221DELTACEP. Keywords: expression comparison 4 cultures of each strain were analyzed.
ORGANISM(S): Streptococcus pyogenes 
2010-05-26 | E-GEOD-9793 | biostudies-arrayexpress
TranscriptomicsTranscriptome comparison of B. anthracis Ames and isogenic sinR-null mutant, UTA21
To establish the SinR regulon in B. anthracis, gene expression of the fully virulent Ames strain and the isogenic sinR-null strains were compared using expression microarray analysis. Cultures of the two B. anthracis strains tested were grown in triplicate in LB broth to mid-exponential phase (O.D...
ORGANISM(S): Bacillus anthracis 
2010-08-01 | E-GEOD-22559 | biostudies-arrayexpress
TranscriptomicsComparison of the CcpA and CovR Transcriptomes in Group A Streptococcus
The goal of this study were to compare the transcriptoms of CcpA and CovR in group A Streptococcus. Isogenic mutant strains were created in which CcpA and CovR were inactivated alone and in combination. The transcriptomes of the four strains (wild-type, CcpA mutant, CovR mutant, and ccpA-covR doub...
ORGANISM(S): Streptococcus sp. 'group A' 
2010-05-06 | E-GEOD-20212 | biostudies-arrayexpress
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