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ProteomicsSUMOylome Profiling in Arabidopsis of Targets Modified by the Sumo Ligase Siz1 During Heat Stress
Ligation is accomplished by a small set of SUMO E3 ligases, with the SAP-MIZ domain-containing (SIZ)-1 and METHYL METHANESULFONATE-SENSITIVE (MMS)-21 ligases having critical roles in stress protection and DNA endoreduplication, respectively. To help identify their corresponding Arabidopsis targets,...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-04-05 | PXD007054 | Pride
Sumo e3 ligases Siz1 Arabidopsis Heat stress Sumo 
UnknownSUMO E3 Ligases GmSIZ1a and GmSIZ1b regulate vegetative growth in soybean .
Not available
S-EPMC5248596 | biostudies-literature
ProteomicsBioE3 enables the identification of bona fide targets of E3 ligases
The post-translational modification of proteins by ubiquitination is a highly regulated process that involves a dynamic, three-step enzymatic cascade, where more than 600 E3 ligases play a critical role in recognizing specific substrates for modification. Separating bona fide targets of E3s from E3-...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041685 | Pride
E3-ligases Bioe3 Ubiquitination Proteomics 
ProteomicsSUMO Proteomics Analyses Identify Protein Inhibitor of Activated STAT-Mediated Regulatory Networks Involved in Cell Cycle and Cell Proliferation
Protein inhibitor of activated STAT (PIAS) are E3 SUMO ligases playing important roles in protein stability and signaling transduction pathways. PIAS proteins are overexpressed in the triple-negative breast cancer cell line MDA-MB-231, and PIAS knockout (KO) results in a reduction in cell proliferat...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD023841 | Pride
Hek293 sumo3m lc-ms/ms pias sumo e3 ligase proteomics 
TranscriptomicsSumoylation at Chromatin Governs Coordinated Repression of a Transcriptionnal Program Essential for Cell Growth and Proliferation
mRNA profiling of WI38 wild-type or overexpressiong the SUMO E3 ligase PIASy in human primary fibroblasts 24h post-infection. The goal of this study is to analyse transcriptional changes in cells over-expressing the SUMO E3 ligase PIASy and to compare them with ChIPseq data for several histones mark...
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MEXP-3776 | biostudies-arrayexpress
UnknownMMS21/HPY2 and SIZ1, two Arabidopsis SUMO E3 ligases, have distinct functions in development.
Not available
S-EPMC3466189 | biostudies-literature
Proteomicsinterferon-induced global cellular SUMOylation Changes
This proteomics dataset was generated to study the changes in SUMO site abundances between control cells and Interferon-alpha treated cells using SILAC. Cells were first fractionated into the cytoplasmic and nuclear fractions. SUMOylated proteins were then purified from these extracts by Ni-NTA via ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081525 | MassIVE
UnknownSUMO E3 ligase activity of TRIM proteins.
Not available
S-EPMC3103664 | biostudies-literature
UnknownNecdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.
Not available
S-EPMC4049815 | biostudies-literature
UnknownBioE3 identifies specific substrates of ubiquitin E3 ligases.
Not available
S-EPMC10667490 | biostudies-literature
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