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ProteomicsMultidimensional Molecular Characteristics of Early-Onset Endometrioid Endometrial Carcinoma, And Potential Predictors Of Response To Fertility Sparing Therapy
Endometrial carcinoma (EC) remains a public health concern with a growing incidence particularly in younger women. Women with early-onset endometrioid EC (EEEC) who wish to maintain fertility are a worldwide concern. To illuminate the molecular characteristics of EEEC, we undertook a large-scale mul...
ORGANISM(S): Homo sapiens (Human) 
2024-04-05 | PXD046507 | Pride
Endometrial carcinoma  early-onset  carcinogen signature  fertility-sparing treatment  siglec10 
UnknownBRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors.
Not available
S-EPMC10124306 | biostudies-literature
UnknownThe short-term effect of laparoscopic sleeve gastrectomy with his angle reconstruction (LSG-His) on gastroesophageal reflux disease.
Not available
S-EPMC12369119 | biostudies-literature
UnknownThe predictive value of atherogenic index of plasma for cardiovascular outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention with LDL-C below 1.8mmol/L.
Not available
S-EPMC10294439 | biostudies-literature
UnknownHabitat-specific differences in plasticity of foliar δ (13)C in temperate steppe grasses.
Not available
S-EPMC4098143 | biostudies-literature
UnknownDevelopment and validation of a new risk assessment model for immunomodulatory drug-associated venous thrombosis among Chinese patients with multiple myeloma.
Not available
S-EPMC10552366 | biostudies-literature
UnknownAdmission high-sensitivity C-reactive protein levels improve the Grace risk score prediction on in-hospital outcomes in acute myocardial infarction patients.
Not available
S-EPMC8922537 | biostudies-literature
UnknownTRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein.
Not available
S-EPMC5006124 | biostudies-literature
ProteomicsComprehensive multi-omics analysis revealed WEE1 as a synergistic lethal target with hyperthermia through CDK super-activation
The role of hyperthermic intraperitoneal chemotherapy (HIPEC) in epithelial ovarian cancer (EOC) is still controversial partly because of the poorly understood mechanism of action. Further an understanding of the underlying mechanisms could identify potential combination therapies. Here, we conduct ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-12 | PXD040849 | Pride
Wee1 Hyperthermia Multi-omics Cdk1 Ovarian cancer Azd1775 
UnknownMTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.
Not available
S-EPMC5915037 | biostudies-literature
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