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MetabolomicsIntegrative analysis of metabolome and transcriptome reveals new insights into formation and regulation of major components of G. leucocontextum and G. lucidum

Ganoderma is a class of medicinal fungi with diverse medicinal effects, of which triterpenoids are one of the main pharmacologically active substances. In this study, sporocarps of two Ganoderma species (G. leucocontextum, a newly discovered species, and G. lucidum, a traditional medicinal specie...

2026-02-08 | MTBLS13871 | MetaboLights
TranscriptomicsAltered gene expression in Werner & Bloom syndromes is associated with sequences having G-quadruplex forming potential
The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their S. cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid structures fo...
ORGANISM(S): Homo sapiens 
2009-12-09 | E-GEOD-19205 | biostudies-arrayexpress
TranscriptomicsSun and shade leaves_2x ambient ozone_020806
Tropospheric ozone causes severe oxidative stress in plants. To investigate the transcriptional responsiveness of adult trees to ozone, fully-expanded sun and shade leaves of mature beech trees were harvested at four time points over the entire vegetation period in 2005 and 2006. Microarray analyses...
ORGANISM(S): Fagus sylvatica 
2011-10-20 | E-GEOD-17416 | biostudies-arrayexpress
TranscriptomicsSun and shade leaves_2x ambient ozone_210605
Tropospheric ozone causes severe oxidative stress in plants. To investigate the transcriptional responsiveness of adult trees to ozone, fully-expanded sun and shade leaves of mature beech trees were harvested at four time points over the entire vegetation period in 2005 and 2006. Microarray analyses...
ORGANISM(S): Fagus sylvatica 
2011-10-20 | E-GEOD-17413 | biostudies-arrayexpress
TranscriptomicsSun and shade leaves_2x ambient ozone_050805
Tropospheric ozone causes severe oxidative stress in plants. To investigate the transcriptional responsiveness of adult trees to ozone, fully-expanded sun and shade leaves of mature beech trees were harvested at four time points over the entire vegetation period in 2005 and 2006. Microarray analyses...
ORGANISM(S): Fagus sylvatica 
2011-10-20 | E-GEOD-17411 | biostudies-arrayexpress
TranscriptomicsSun and shade leaves_2x ambient ozone_190905
Tropospheric ozone causes severe oxidative stress in plants. To investigate the transcriptional responsiveness of adult trees to ozone, fully-expanded sun and shade leaves of mature beech trees were harvested at four time points over the entire vegetation period in 2005 and 2006. Microarray analyses...
ORGANISM(S): Fagus sylvatica 
2011-10-20 | E-GEOD-17415 | biostudies-arrayexpress
TranscriptomicsSun and shade leaves_2x ambient ozone_120505
Tropospheric ozone causes severe oxidative stress in plants. To investigate the transcriptional responsiveness of adult trees to ozone, fully-expanded sun and shade leaves of mature beech trees were harvested at four time points over the entire vegetation period in 2005 and 2006. Microarray analyses...
ORGANISM(S): Fagus sylvatica 
2011-10-20 | E-GEOD-17414 | biostudies-arrayexpress
ProteomicsMitochondrial RelA empowers mtDNA G-quadruplex formation for hypoxia adaptation in cancer cells
Mitochondrial DNA (mtDNA) G-quadruplexes (G4s) have been proposed as potential regulators of energy metabolism. However, numerous aspects of this process remain elusive. In our quest, employing a chemical-genetic screening strategy, we successfully identified the JAK/STAT3 pathway as the primary reg...
ORGANISM(S): Homo sapiens (Human) 
2024-05-13 | PXD043639 | Pride
Huamn G-quadruplex Mitochondria Lc-ms/ms 
GenomicsGenomic G-Quadruplex folding and unfolding following global DNA demethylation
Genomic G-Quadruplex folding and unfolding following global DNA demethylation
PRJNA804153 | ENA
TranscriptomicsSun and shade leaves_2x ambient ozone_270606
Tropospheric ozone causes severe oxidative stress in plants. To investigate the transcriptional responsiveness of adult trees to ozone, fully-expanded sun and shade leaves of mature beech trees were harvested at four time points over the entire vegetation period in 2005 and 2006. Microarray analyses...
ORGANISM(S): Fagus sylvatica 
2011-10-20 | E-GEOD-17419 | biostudies-arrayexpress
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