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ProteomicsRequirement of Rbx1 Cullin-RING ligase E3 and Ube2m neddylation E2 in the maintenance of the fitness of Treg cells
the Ube2m-Rbx1 axis is required for the maintenance of homeostasis and functions of Treg cells; and Rbx1 has Ube2m-independent roles in the fitness of Treg cells, suggesting a layer of complexity in neddylation activation of CRLs.
ORGANISM(S): Mus Musculus 
2021-12-03 | PXD030144 |
ProteomicsLysine methylome features in EZH2 wild-type and mutant lymphoma cell line
We used EZH2i-targeted hematological malignancies as an examples and focused on molecular characterization of EZH2 Y641 mutant hematological cell lines. We used the proteomic strategies and compared the protein expression level and lysine methylation level (including mono-, di-, and trimethylaiton) ...
ORGANISM(S): Homo Sapiens 
2019-12-17 | PXD016779 |
ProteomicsA proteomic landscape of macrophage in mouse tissues
Macrophages, locating in essentially all tissues, are critical for innate immune responses and involved in the tissue homeostasis. Distinct macrophages populations in different tissues exhibited diverse gene expressions and biological processes. Previous studies have accessed the molecular signature...
ORGANISM(S): Mus Musculus 
2022-10-28 | PXD021583 |
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