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ProteomicsMitophagy Mitigates Mitochondrial Fatty Acid β-oxidation Deficient Cardiomyopathy
The healthy heart relies on mitochondrial fatty acid β-oxidation (FAO) for ATP production but can exhibit marked metabolic flexibility in response to diverse physiological and pathological circumstances 1-4. Mutations or deficiencies in FAO enzymes can lead to a spectrum of symptoms, ranging from mu...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-14 | PXD052216 | Pride
Mitophagy  mitochondrial  fatty acid β-oxidation  usp30  cardiomyopathy  pink1  parkin 
ProteomicsThe NAE1-mediated Neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells
Cells were lysed with TFA, and precipitated with cold acetone. The precipitates were transferred to E3filters and digestion was performed overnight with trypsin. The peptides were desalted with StageTips, and were analyzed on Eclipse Orbitrap with DIA mode. For MS1, the resolution was set to 120,00...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-27 | MSV000094179 | MassIVE
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