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TranscriptomicsTranslational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
Ubiquitous expression of ALS-causing mutations in superoxide dismutase 1 (SOD1) provoke non-cell autonomous paralytic disease. By combining ribosome affinity purification and high-throughput sequencing, a cascade of mutant SOD1-dependent, cell type-specific changes are now identified. Initial mutant...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-74724 | biostudies-arrayexpress
ProteomicsUbiquitin Ligase Enzyme FANCL Inhibits Peste des petits ruminants Virus Replication by Inducing Type I Interferon Production through Promoting Phosphorylation of TBK1
Peste des petits ruminants virus (PPRV) infection causes highly contagious and severe disease in domestic and wild ruminants. It is widely reported that PRRV infection causes considerable innate immunosuppression in its host and promotes viral replication. However, how does the host rescue the innat...
ORGANISM(S): Ovis aries 
2021-07-26 | PXD022271 | Pride
Peste des petits ruminants virus  quantitative proteomics  fancl  innate immune response  tbk1 
ProteomicsTumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic antigenic peptides
Mass spectrometry for HLA class I (HLA-I) peptidome of human breast cancer samples identified an HLA-I binding peptide encoded by circRNA.
ORGANISM(S): Homo Sapiens Mus Musculus 
2023-12-21 | PXD041427 |
ProteomicsProteomic and Acetylome Alterations in Obesity-related Osteoarthritic Mouse Cartilage
Male mice aged 4 weeks were housed under controlled conditions and assigned to either a normal diet or a high-fat diet for 16 weeks to establish an obesity model. At 12 weeks, osteoarthritis was induced using the destabilization of the medial meniscus procedure under anesthesia, while sham-operated ...
ORGANISM(S): Mus Musculus 
PXD062707 |
ProteomicsA multi-omics dataset of human transcriptome and proteome stable reference
In recent years, the development of high-throughput omics technology has greatly promoted the development of biomedicine. However, the poor reproducibility of omics techniques limits its application. It is necessary to use standard reference materials of complex RNAs or proteins to test and calibrat...
ORGANISM(S): Homo Sapiens 
PXD041292 |
TranscriptomicsALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP
The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease ALS, is demonstrated to directly bind to the U1-snRNP and SMN complexes. ALS-causative mutations in FUS/TLS are shown to abnormally enhance their interaction with SMN and reduce interaction with U1-snRN...
ORGANISM(S): Homo sapiens 
2015-02-10 | E-GEOD-64078 | biostudies-arrayexpress
ProteomicsARIH1 Signaling Promotes Anti-tumor Immunity by Targeting PD-L1 for Proteasomal Degradation
We find EGFR inhibitors promote PD-L1 ubiquitination and proteasomal degradation following GSK3α-mediated phosphorylation of Ser279/Ser283.
ORGANISM(S): Homo Sapiens 
2021-03-01 | PXD024452 |
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