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UnknownThe lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5.
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S-EPMC6125951 | biostudies-literature
TranscriptomicsGenome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes
Stat5+/- mice were bred into the C57BL/6 background. Stat5+/- mice were intercrossed and mouse embryonic fibroblasts (MEFs) were isolated from 12.5-13.5-day WT or Stat5-/- fetuses. The retroviral-expression vector carrying a wild-type Stat5A gene based on an MSCV-IRES-GFP backbone (gift from Richard...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-33688 | biostudies-arrayexpress
TranscriptomicsProtection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling
Imbalances in glucose and energy homeostasis are at the core of the worldwide epidemic of obesity and diabetes. Here, we illustrate an important role of the TGF-beta/Smad3 signaling pathway in regulating glucose and energy homeostasis. Smad3 deficient mice are protected from diet-induced obesity and...
ORGANISM(S): Mus musculus 
2011-07-12 | E-GEOD-28598 | biostudies-arrayexpress
ProteomicsProximity tagging identified mitofusins stimulating mitochondria and peroxisomes clustering
we applied a proximity tagging system PUP-IT to PEX ubiquitin ligase to identify their proximal proteins. Surprisingly, we identified many mitochondrial proteins in the proximity of peroxisomes. We further validated the interaction between PEX and mitofusins (MFNs).
ORGANISM(S): Homo Sapiens 
2022-03-19 | PXD032661 |
ProteomicsCBX4 contributes to HIV-1 latency by forming phase-separated nuclear bodies and SUMOylating EZH2
Molecular mechanisms of HIV-1 latency have been studied extensively to achieve a functional cure for the acquired immunodeficiency syndrome (AIDS). To develop more promising latency-reversing agents (LRAs) to efficiently reactivate the latent reservoir which is subsequently eliminated by immune surv...
ORGANISM(S): Homo Sapiens 
2022-01-14 | PXD031011 |
TranscriptomicsEpigenetic silencing of Th1 chemokines shapes tumor immunity, immunotherapy and patient outcome [shEZH2]
To define the gene profile altered by EZH2 and H3K27me3 in response to IFNg, we performed several microarrays in primary ovarian cancer cells transfected with shEZH2 or treated with GSK126. We found that 155 and 124 genes were altered by shEZH2 and GSK126 treatment, respectively, and 20 genes were i...
ORGANISM(S): Homo sapiens 
2015-08-11 | E-GEOD-71870 | biostudies-arrayexpress
TranscriptomicsEpigenetic silencing of Th1 chemokines shapes tumor immunity, immunotherapy and patient outcome [GSK126]
To define the gene profile altered by EZH2 and H3K27me3 in response to IFNg, we performed several microarrays in primary ovarian cancer cells transfected with shEZH2 or treated with GSK126. We found that 155 and 124 genes were altered by shEZH2 and GSK126 treatment, respectively, and 20 genes were i...
ORGANISM(S): Homo sapiens 
2015-08-11 | E-GEOD-71869 | biostudies-arrayexpress
TranscriptomicsSkeletal Muscle Contraction Reduces Effects of Unloading on Bone Independently from the Central Nervous System: Studies Using Functional Electrical Stimulation after Spinal Cord Transection
Spinal cord injury (SCI) causes severe bone loss and disrupts connections between higher centers in the central nervous system (CNS) and bone. Muscle contraction elicited by functional electrical stimulation (FES) partially protects against loss of bone but cellular and molecular events by which th...
ORGANISM(S): Rattus norvegicus 
2012-06-27 | E-GEOD-30301 | biostudies-arrayexpress
ProteomicsProteogenomic analysis of chemo-refractory high grade serous ovarian cancer
To improve our understanding of the molecular basis of chemo-refractory high grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two independent validation cohorts (spanning four academic centers...
ORGANISM(S): Homo Sapiens 
PXD040742 | panorama
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