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ProteomicsIonizable polymeric micelles (IPMs) for efficient siRNA delivery
Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance. We design three ionizable oligo-mers (IOs) that, with PLA-PEG, form Ionizable Polymeric Micelles (IPMs), a potential siRNA delivery system, which can achie...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-21 | PXD057444 | Pride
Hsp47 Protein corona Hmgb1 Hepatic fibrosis Fibroblast activation protein inhibitor (fapi) Nucleic acid delivery Ionizable polymeric micelles (ipms) Hepatic stellate cells 
ProteomicsProteomic studies of the mechanism of cytotoxicity, induced by palytoxin on HaCaT cells
Palytoxin (PLTX) is a polyether Marine toxin isolated from sea anemones. It is one of the most toxic non-protein substances, causing many people to be poisoned every year and die in severe cases. With its known impact on Na+, K+-ATPase, much still remain unclear about the mechanism of PLTX action. H...
ORGANISM(S): Homo Sapiens 
2022-03-24 | PXD032777 |
ProteomicsIdentification of TRADD phosphorylation sites
We re-introduced Flag-mTRADD into Tradd-/- MEFs, and identified the phosphorylation sites of TRADD which were induced by TNF and inhibited by TAK1 inhibitor 5Z7 using mass spectrometry. We found that TAK1 could mediate the phosphorylation of multiple sites in TRADD upon TNF stimulation. We next perf...
ORGANISM(S): Homo Sapiens 
2024-10-05 | PXD056588 |
ProteomicsChloroplast Nanotechnology for General Health
Chloroplast Nanotechnology for General Health using Omics analysis
ORGANISM(S): Spinacia Oleracea 
2026-03-21 | PXD076001 |
ProteomicsTargeting the Golgi apparatus enhances PD-L1 blockade and synergizes with oxaliplatin to improve immunotherapy efficacy
Proteomic profiling of differentially expressed proteins of 4T1 cells induced by liposome.
ORGANISM(S): Mus Musculus 
2026-02-03 | PXD073979 |
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