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TranscriptomicsMitochondrial superoxide dismutase controls metabolic plasticity in pancreatic cancer
Reactive oxygen species have been established to play a critical role in pancreatic carcinogenesis. One of the main antioxidant enzymes is mitochondrial superoxide dismutase (Sod2). Sod2 has been shown to affect tumor initiation and metastatic progression in various cancer types. The impact of Sod2 ...
ORGANISM(S): Mus musculus 
2025-12-23 | E-MTAB-16320 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Sod2-/- and Sod2+/+ erythroblasts.
The mitochondrial superoxide dismutase (SOD2) is a major antioxidant protein which detoxifies superoxide anion radicals generated by mitochondrial respiration (Weisiger and Fridovich, J. Biol. Chem. 1973). We designed a model of oxidative stress-induced anemia caused by SOD2-deficiency (Friedman et...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-8726 | biostudies-arrayexpress
GenomicsDNA-seq of mitochondrial DNA from mouse heart that is both heart SOD2 knockout and deficient for mitochondrial DNA repair
To study whether increase in mitochondrial oxidative stress (SOD2 removal) and decrease in mitochondrial DNA repair (Ogg1 dMTS) results into increase in mitochondrial DNA mutation load. Oxidative stress has been suggested to induce mutations in mtDNA. To verify this, we extracted and sequenced (Illu...
ORGANISM(S): Mus musculus 
2018-07-13 | E-MTAB-6533 | biostudies-arrayexpress
ProteomicsMass Spectometry Analysis of Inhibition of SOD2-mediated protein degradation
Peptide samples were analysed by a shot-gun approach as described recently (Stieglitz et al., 2022). Raw MS data were processed using Max Quant (version 2.0, Cox and Mann 2008), Perseus software (version 2.0.6.0)(Tyanova et al.,2016), and human entries of uniprot DB. Proteins were stated identified ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-15 | MSV000094325 | MassIVE
TranscriptomicsRNA-seq of mouse heart that is both heart SOD2 knockout and deficient for mitochondrial DNA repair
To study whether increase in mitochondrial oxidative stress (SOD2 removal) and decrease in mitochondrial DNA repair (Ogg1 dMTS) results into increase in mutations in mitochondrial RNA (mtRNA). Oxidative stress has been suggested to induce mutations in mtDNA and as DNA is used as a template in transc...
ORGANISM(S): Mus musculus 
2018-07-13 | E-MTAB-6534 | biostudies-arrayexpress
TranscriptomicsArabidopsis thaliana Transcriptome under Salt Stress
CuZn-superoxide dismutase (CuZn-SOD) and ascorbate peroxidase (APX) constitute first line of defence against oxidative stress. In the present study, PaSOD and RaAPX genes from Potentilla atrosanguinea and Rheum australe, respectively were overexpressed individually as well as in combination in Arabi...
ORGANISM(S): Arabidopsis thaliana 
2014-10-06 | E-MTAB-4434 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of E. coli BL21(DE3)::TN7T7 -SOD to analyze the cellular response of this plasmid-free expression system to high level expression of recombinant human super-oxide-dismutase
This transcription profiling time course experiment was conducted in order to analyze the cellular response of the plasmid-free expression system E.coli BL21(DE3)::TN7 to high level expression of recombinant human super-oxide-dismutase (SOD).Three biological replicates were generated by usi...
ORGANISM(S): Escherichia coli 
2013-05-31 | E-MARS-24 | biostudies-arrayexpress
GenomicsMitochondrial superoxide dismutase controls metabolic plasticity in pancreatic cancer
Mitochondrial superoxide dismutase controls metabolic plasticity in pancreatic cancer
PRJEB104508 | ENA
ProteomicsMitochondria enriched proteome from heart of heart Sod2 knockout mice LC MS/MS
Superoxide dismutases (SOD) convert superoxide to hydrogen peroxide and therefore provide an important ROS defence mechanism. SOD2 is the sole superoxide dismutase in mitochondrial matrix and thus SOD2 knockout mice can be utilized to analyse what effects increased oxidative stress has on mitochondr...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-06 | PXD008998 | Pride
C57bl/6n Heart Sod2 Superoxide dismutase 2 Mitochondria Mouse Mnsod2 
GenomicsEnterocyte Superoxide Dismutase 2 Deletion Drives Hyperinsulinemia and Obesity
Enterocyte Superoxide Dismutase 2 Deletion Drives Hyperinsulinemia and Obesity
PRJNA664402 | ENA
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