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MetabolomicsCell of origin epigenetic priming determines susceptibility to Tet2 mutation

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights
TranscriptomicsTat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNAs by HIV-1
Herein expression trends of host miRNA were measured in CEMx174 lymphocytes infected with HIV-1NL4-3 or derivative strains deficient in Tat RSS activity (RSS) or vif-/vpr (VV), or unexposed to virus. As expected from previous studies, miRNA trends were different in naive and HIV-1 infected cells. ...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-21892 | biostudies-arrayexpress
TranscriptomicsmiRNA expression in myeloid-derived suppressor cells (MDSCs) treated with or without whole ?-glucan particles (WGP)
Murine MDSCs isolated from the spleens of Lewis lung carcinoma mice were treated with or without WGP, and then miRNA array was used to analyze the differentailly expressed miRNAs. Murine MDSCs were isolated from the spleens of Lewis lung carcinoma tumor-bearing mice, and the sorted MDSCs were stimul...
ORGANISM(S): Mus musculus 
2015-06-26 | E-GEOD-67578 | biostudies-arrayexpress
TranscriptomicsBRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas
Low-grade ovarian serous carcinomas are believed to arise via an adenoma-serous borderline tumor-serous carcinoma sequence. In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without adjacent serous borderline tumor shared similar regions of loss of hetero...
ORGANISM(S): Homo sapiens 
2011-03-04 | E-GEOD-27659 | biostudies-arrayexpress
TranscriptomicsNormal human mammary tissues from BRCA1 mutation carriers, non-BRCA1/2 mutation carriers and normal women
Gene expression profiles of normal human mammary tissue from BRCA1 mutation carriers, non-BRCA1/2 mutation carriers and normal women. RNA was prepared from normal breast tissue (confirmed by pathology) from reduction mammoplasties (n=5) and prophylactic mastectomies of known BRCA1 (n=7) and non-BRC...
ORGANISM(S): Homo sapiens 
2009-08-01 | E-GEOD-17072 | biostudies-arrayexpress
TranscriptomicsIntegrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia
Background: MicroRNAs are regulators of gene expression, mainly functioning by decreasing mRNA levels of their multiple targets. Deregulated microRNA expression has been shown for acute myeloid leukemia, a disease also characterized by altered gene expression associated with distinct genomic aberrat...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-31644 | biostudies-arrayexpress
GenomicsAAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (amplicon)
AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (amplicon)
PRJNA743041 | ENA
ProteomicsTetrahedral DNA Nanostructure-delivered Suppressor tRNA Ameliorates Nephropathy in COL4A5 Nonsense Mutation-mediated Alport Syndrome Mice
Nonsense mutations introduce premature termination codons (PTCs) that trigger mRNA degradation and underlie genetic diseases, including Alport syndrome (AS). Suppressor tRNAs (sup-tRNAs) are potential therapies for such disorders, as they can precisely readthrough PTCs and restore full-length protei...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD078106 | Pride
Col4a5 Suppressor trna 
GenomicsAAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (tRNA_charging)
AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (tRNA_charging)
PRJNA781652 | ENA
GenomicsAAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (mim-tRNA)
AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (mim-tRNA)
PRJNA743039 | ENA
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