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TranscriptomicsTranscription profiling of mouse SCN after 30-min light pulse
The transmission of information about the photic environment to the circadian clock involves a complex array of neurotransmitters, receptors, and second messenger systems. Using laser capture microscopy and microarray analysis, a population of genes rapidly induced by light in the suprachiasmatic n...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6904 | biostudies-arrayexpress
ProteomicsM.musculus - Suprachiasmatic nucleus, iBAQ (Chiangetal,plosgenetics.2014)
abundance based on iBAQ, Interaction consistency score: 15.5, Coverage: 18
ORGANISM(S): 10090 
2014-00-00 | 1300563876 | PAXDB
ProteomicsSCN Proteomic Study:electroacupuncture induced circadian control in Suprachiasmatic Nucleus
Recent reports highlight phosphorylation as a major role in the regulation of sleep-wake cycles, to a lesser extent, the phosphoproteome in Suprachiasmatic Nucleus (SCN) is not well understood. We use multiplex tandem mass tag (TMT) - labelling coupled with liquid chromatography-mass spectrometry (L...
ORGANISM(S): Mus Musculus 
2021-10-31 | PXD029450 |
TranscriptomicsTranscription profiling of mouse NIH3T3 Fibroblasts circadian expression, comparison with rhythmic gene expression in SCN2.2 Cells and the rat SCN
To screen for specific circadian outputs that may distinguish the pacemaker in the mammalian suprachiasmatic nucleus (SCN) from peripheral-type oscillators in which the canonical clockworks are similarly regulated in a circadian manner, the rhythmic behavior of the transcriptome in forskolin-stimula...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5810 | biostudies-arrayexpress
TranscriptomicsSCN lightpulse timecourse
The aim of the experiment was to identify genes in the mouse suprachiasmatic nucleus whose expression was altered by exposure to a light pulse of 400 lux at CT16 (subjective night). C57BL/6 male mice were entrained to a 12:12 LD cycle and given a 30 min 400 lux light pulse at CT16. Punches of SCN ti...
ORGANISM(S): Mus musculus 
2013-12-16 | E-MEXP-3933 | biostudies-arrayexpress
ProteomicsMouse SCN in LC-MSMS - The suprachiasmatic nucleus (SCN) acts as the central clock to coordinate circadian oscillations in mammalian behavior, physiology and gene expression. Despite our knowledge of the circadian transcriptome of the SCN, how it impacts genome-wide protein expression is not well understood. Here, we interrogated the murine SCN proteome across the circadian cycle using SILAC-based quantitative mass spectrometry.
The suprachiasmatic nucleus (SCN) acts as the central clock to coordinate circadian oscillations in mammalian behavior, physiology and gene expression. Despite our knowledge of the circadian transcriptome of the SCN, how it impacts genome-wide protein expression is not well understood. Here, we inte...
ORGANISM(S): Mus musculus (Mouse) 
2014-09-10 | PXD000778 | Pride
Circadian rhythm Mouse Suprachiasmatic nucleus Lc-ms/ms 
TranscriptomicsTemporal transcriptomics suggest that twin-peaking genes reset the clock
The mammalian suprachiasmatic nucleus (SCN) drives daily rhythmic behavior and physiology, yet a detailed understanding of its coordinated transcriptional programmes is lacking. To reveal the true nature of circadian variation in the mammalian SCN transcriptome we combined laser-capture microdissect...
ORGANISM(S): Mus musculus 
2015-11-03 | E-GEOD-72095 | biostudies-arrayexpress
GenomicsReshaping Circadian Metabolism in the Suprachiasmatic Nucleus and Prefrontal Cortex by Nutritional Challenge
Reshaping Circadian Metabolism in the Suprachiasmatic Nucleus and Prefrontal Cortex by Nutritional Challenge
PRJNA660021 | ENA
TranscriptomicsTranscriptome expressed in the mouse suprachiasmatic nucleus
This array set was used to identify the genes that are highly expressed in the mouse suprachiasmatic nucleus (SCN). Because pharmacological inhibition of Gai/o activity with pertussis toxin hampers intercellular synchronization and causes dampened rhythms of the entire SCN, we hypothesized that memb...
ORGANISM(S): Mus musculus 
2011-04-22 | E-GEOD-28574 | biostudies-arrayexpress
TranscriptomicsCircadian regulation of gene expression in the SCN (RNA-seq)
We performed a circadian RNA expression profile of the mammalian biological clock, the suprachiasmatic nucleus (SCN) in C57/BL6 mice, at 2-hour resolution using microarrays, and at 6-hour resolution using RNA-seq.  8 samples total covering 8 time points, with no replicates. SCN samples from mouse b...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-70391 | biostudies-arrayexpress
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