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GenomicsAP2gamma ChIPseq
As a part of a modelling experiment for transcriptional control of mouse primordial germ cell specification, the transcription factor AP2gamma was stably expressed in the mouse p19 embryonal carcinoma cell line and its genome wide binding sites were defined using ChIPseq.
ORGANISM(S): Mus musculus 
2013-07-17 | E-MTAB-1600 | biostudies-arrayexpress
GenomicsBLIMP1 ChIPseq
As a part of a modelling experiment for transcriptional control of mouse primordial germ cell specification, the transcription factor BLIMP1 was transiently expressed in the mouse p19 embryonal carcinoma cell line and its genome wide binding sites were defined using ChIPseq.
ORGANISM(S): Mus musculus 
2013-07-17 | E-MTAB-1599 | biostudies-arrayexpress
GenomicsNANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers [ChIP-seq]
Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in unipotent primordial germ cells (PGC) in mice1, where its precise role is yet unclear2-4. We investigated this in an in vitro model, where naïve pluripotent embryonic stem cells (ESCs) cultured in bFGF/Act...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-71932 | biostudies-arrayexpress
GenomicsA critical but divergent role of PRDM14 in human primordial germ cell fate revealed by inducible degrons [RNA-seq]
A critical but divergent role of PRDM14 in human primordial germ cell fate revealed by inducible degrons [RNA-seq]
PRJNA576723 | ENA
GenomicsA critical but divergent role of PRDM14 in human primordial germ cell fate revealed by inducible degrons [ChIP-seq]
A critical but divergent role of PRDM14 in human primordial germ cell fate revealed by inducible degrons [ChIP-seq]
PRJNA576728 | ENA
GenomicsA critical but divergent role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
A critical but divergent role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
PRJNA576722 | ENA
UnknownInitiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte.
Not available
S-EPMC1369137 | biostudies-literature
TranscriptomicsPRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos
Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which entails comprehensive erasure of DNA methylation. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process. Here we show that conditional los...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-61216 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of embryonal carcinoma cell line P19 with or without expressoin of Blimp1-EGFP fusion protein over a 48-hour time-course to study the role of Blimp1 in transcription regulation in pluripotent embryonic cells
Genome-wide expression analysis was performed with the aim of investigating transcriptional changes mediated by the transcription factor B lymphocyte-induced maturation protein-1 (Blimp1) in the context of pluripotent embryonic cells, with the aim of drawing parallels to its functions in mouse primo...
ORGANISM(S): Mus musculus 
2013-05-11 | E-MTAB-865 | biostudies-arrayexpress
GenomicsEpigenetic resetting in the human germline entails histone modification remodelling [ChIP-Seq]
Epigenetic resetting in the human germline entails histone modification remodelling [ChIP-Seq]
PRJNA889528 | ENA
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