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TranscriptomicsTranscriptional responses of Mycobacterium tuberculosis to lung surfactant
This study uses microarray analyses to examine gene expression profiles for Mycobacterium tuberculosis (Mtb) induced by exposure in vitro to bovine lung surfactant preparations that vary in apoprotein content: (i) whole lung surfactant (WLS) containing the complete mix of endogenous lipids and surfa...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-18 | E-GEOD-14005 | biostudies-arrayexpress
TranscriptomicsSurfactant Protein C knockout
Study the Role of Surfactant Protein C in Innate Lung Defense. Gene expression profiles comparison between isolated TYPE II cells from SPC(-/-) and control litter mates.
ORGANISM(S): Mus musculus 
2012-08-21 | E-GEOD-35989 | biostudies-arrayexpress
GenomicsPulmonary surfactant protein D reduces lung cancer progression associated with decreased IL-4/STAT6 signaling
Pulmonary surfactant protein D reduces lung cancer progression associated with decreased IL-4/STAT6 signaling
PRJNA1050764 | ENA
TranscriptomicsGpr116 regulates pulmonary surfactant pool size
The amount of pulmonary surfactant within type II cells and in the alveolar space, referred to as surfactant pool sizes, are tightly regulated. The molecular pathways that sense and regulate surfactant pool size within the alveolus have not been identified and constitute a fundamental knowledge gap ...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-41417 | biostudies-arrayexpress
TranscriptomicsTranscription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function.
Pulmonary alveolar proteinosis (PAP) results from a dysfunction of alveolar macrophages (AMs), chiefly due to disruptions in the signaling of granulocyte macrophage colony-stimulating factor (GM-CSF). We found that mice deficient for the B lymphoid transcription repressor BTB and CNC homology 2 (Bac...
ORGANISM(S): Mus musculus 
2014-01-15 | E-GEOD-54050 | biostudies-arrayexpress
GenomicsPulmonary effects of ozone and allergen exposure in the absence of surfactant protein-D in mice.
Pulmonary effects of ozone and allergen exposure in the absence of surfactant protein-D in mice.
PRJNA436021 | ENA
ProteomicsSurfactant-assisted one-pot sample preparation for label-free single-cell proteomics
Large numbers of cells are generally required for quantitative global proteome profiling due to the significant surface adsorption losses associated with sample processing. Such bulk measurement obscures important cell-to-cell variability (cell heterogeneity) and makes proteomic profiling impossible...
ORGANISM(S): Homo Sapiens 
2021-03-11 | PXD022827 | panorama
GenomicsJejunal gene expression in surfactant protein D (Sftpd) knockout and wild-type mice after doxorubicin-induced intestinal toxicity
Jejunal gene expression in surfactant protein D (Sftpd) knockout and wild-type mice after doxorubicin-induced intestinal toxicity
PRJNA1477982 | ENA
ProteomicsQuantification of surfactant protein D (SPD) in human serum by liquid chromatography-mass spectrometry (LC-MS)
Quantification of intact proteins in complex biological matrices by liquid chromatography-mass spectrometry (LC-MS) is a promising analytical strategy but is technically challenging, notably for concentrations at or below the ng/mL level. Therefore, MS-based protein quantification is mostly based on...
ORGANISM(S): Homo sapiens (Human) 
2021-04-12 | PXD013415 | Pride
Biomarker Copd Lc-ms Immunoprecipitation Quantification Methionine oxidation 
TranscriptomicsPulmonary effects of ozone and allergen exposure in the absence of surfactant protein-D in mice.
Ozone and allergen inhalation causes pulmonary inflammation and impairs lung function in mice. These effects are heightened in the absence of the immunosuppressive surfactant protein-D. Increased expression of inflammatory mediators is critical for the initiation of inflammation and impairment of lu...
ORGANISM(S): Mus musculus 
2019-04-30 | GSE111155 | GEO
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