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MetabolomicsGut Bacteroides act in a microbial consortium to cause susceptibility to severe malaria

Malaria, caused by Plasmodium species, remains a significant cause of morbidity and mortality globally. Gut bacteria can influence the severity of malaria, but the contribution of specific bacteria to the risk of severe malaria is unknown. Here, multiomics approaches demonstrate specific...

2023-09-13 | MTBLS3449 | MetaboLights
MetabolomicsSusceptibility to febrile malaria is associated with an inflammatory gut microbiome

Malaria is a major public health problem, but many of the factors underlying the pathogenesis of this disease are not well understood. Here, we demonstrate in Malian children that susceptibility to febrile malaria following infection with Plasmodium falciparum is associated with the comp...

2024-09-13 | MTBLS2247 | MetaboLights
MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
MetabolomicsNitrate Reductase NarGHJI Modulates Vancomycin Susceptibility by Coordinating Cell Wall Remodeling and Agmatine Metabolism in Staphylococcus aureus
Staphylococcus aureus is a ubiquitous pathogen responsible for a wide range of severe infections. Our previous work established that the nitrate reductase NarGHJI modulates bacterial pathogenicity through regulation of the agr system, yet its role in antibiotic resistance remains poorly understood. ...
2026-07-07 | MTBLS14968 | MetaboLights
MetabolomicsMicrobiome-produced nicotinic acid controls colon regional identity and injury susceptibility

Regional structure of the intestinal epithelium is critical for its function and is associated with the risk of specific gut diseases. However, how regionalization is established and how it influences disease susceptibility remains poorly understood. Here, we investigated the role of the gut micr...

2026-03-27 | MTBLS12063 | MetaboLights
MetabolomicsEffects of gut microbiota on the susceptibility of ischemic stroke in mice

Ischemic stroke is a highly prevalent disease with constrained therapeutic options, and recent studies suggest that gut microbiota significantly influences its development. However, it remains unclear whether the gut microbiota has an impact on the susceptibility of ischemic stroke. Here, we aime...

2026-02-11 | MTBLS10583 | MetaboLights
MetabolomicsPhosphatidylcholine in wheat anthers is a susceptibility factor for Fusarium head blight
Fusarium head blight is a devastating wheat disease that initiates at flowering, with anthers as the preferred infection site. However, the anther-derived molecules driving this susceptibility remain elusive. Here, we identify anther-enriched phosphatidylcholine, particularly PC(18:2/18:2) and PC(16...
2026-06-23 | MTBLS14814 | MetaboLights
MetabolomicsAftpo3 and Afdur3, the Aspergillus fumigatus Plasma Membrane Transporters of Polyamines, Regulate Polyamine Homeostasis and Itraconazole Susceptibility

Aspergillus fumigatus is a notorious opportunistic pathogen that causes Invasive Aspergillosis (IA) infections with high mortality in immunosuppressed individuals. Long-term antifungal drug azole abuse in clinical treatment and agriculture renders it ineffectual or drug resistant. Drug resistance...

2020-12-21 | MTBLS1739 | MetaboLights
MetabolomicsMetabolomic study on a schizophrenia and type 2 diabetes susceptibility gene
Not available
ORGANISM(S): Homo sapiens 
ST000568 | MetabolomicsWorkbench
MetabolomicsCell of origin epigenetic priming determines susceptibility to Tet2 mutation

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights
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