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TranscriptomicsLow dose irradiation enhances gene targeting in human pluripotent stem cells
Human pluripotent stem cells (hPSCs) are now being used for both disease modeling and cell therapy. However, efficient homologous recombination (HR) is often crucial to develop isogenic control or reporter lines. Here we show that limited low dose irradiation (LDI) using either γ-ray or X-ray ex...
ORGANISM(S): Homo sapiens 
2016-03-22 | E-GEOD-68328 | biostudies-arrayexpress
ProteomicsIn vitro and in vivo proteomic comparison of human neural progenitor cell-induced photoreceptor survival
Retinal degenerative diseases are some of the leading causes of blindness with few treatments. Various cell-based therapies have aimed to slow the progression of vision loss by preserving light-sensing photoreceptor cells. A subretinal injection of human neural progenitor cells (hNPCs) into the Roya...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-12-17 | PXD011491 | Pride
Retinal degeneration Cell therapy Stem cells Neural progenitors Retina 
ProteomicsAn iPSC Model of Early Onset Parkinson's Disease
Early onset Parkinson’s Disease (onset <50 years) accounts for between 10-20 percent of all patients. While some of these cases are associated with specific mutations, the majority are sporadic where the cause is unknown. We generated induced pluripotent stem cells from sporadic early onset patients...
ORGANISM(S): Homo sapiens (Human) 
2019-12-06 | PXD011326 | Pride
Human Parkinson's disease Ipsc 
UnknownHD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
Not available
S-EPMC4424959 | biostudies-literature
UnknownWorld Heart Federation Roadmap on Atrial Fibrillation - A 2020 Update.
Not available
S-EPMC8162289 | biostudies-literature
UnknownAntiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication.
Not available
S-EPMC7969873 | biostudies-literature
UnknownRoadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit.
Not available
S-EPMC10630271 | biostudies-literature
UnknownGenome-wide Analyses Identify KIF5A as a Novel ALS Gene.
Not available
S-EPMC5867896 | biostudies-literature
UnknownDevelopmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice.
Not available
S-EPMC5610046 | biostudies-literature
UnknownIdentifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data.
Not available
S-EPMC10766562 | biostudies-literature
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