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ProteomicsBioID2 interactome of wild-type SYCP1 versus the D918–942 mutant
This dataset comprises a tandem mass tag (TMT)–based quantitative proteomic analysis of proteins proximal to SYCP1 identified using BioID proximity labelling. Two independent BioID experiments were performed using distinct SYCP1 constructs: an N-terminal Myc-tagged SYCP1 and a C-terminal HA-tagged S...
ORGANISM(S): Homo sapiens (Human) 
2026-04-30 | PXD072359 | Pride
Sycp1  bioid  proximity labeling 
TranscriptomicsCUT&Tag profiling of SYCP1 genomic occupancy in MCF7 breast cancer adenocarcinoma cells upon SYCP1 overexpression
Through various approaches we demonstrate that SYCP1 is aberrantly re-expressed in tumor cells, where it actively promotes DNA damage repair, cell cycle progression, and malignant growth. SYCP1 binds chromatin at regulatory elements and directly controls transcriptional programs governing genome mai...
ORGANISM(S): Homo sapiens 
2026-03-20 | E-MTAB-15852 | biostudies-arrayexpress
GenomicsCUT&Tag profiling of SYCP1 genomic occupancy in MCF7 breast cancer adenocarcinoma cells upon SYCP1 overexpression
CUT&Tag profiling of SYCP1 genomic occupancy in MCF7 breast cancer adenocarcinoma cells upon SYCP1 overexpression
PRJEB101492 | ENA
UnknownStructural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.
Not available
S-EPMC7614228 | biostudies-literature
GenomicsEffect of CRISPR/Cas9-mediated SYCP1 gene expression depletion in MCF7 breast adenocarcinoma cells (RNA-seq)
Effect of CRISPR/Cas9-mediated SYCP1 gene expression depletion in MCF7 breast adenocarcinoma cells (RNA-seq)
PRJEB101586 | ENA
TranscriptomicsEffect of CRISPR/Cas9-mediated SYCP1 gene expression depletion in MCF7 breast adenocarcinoma cells (RNA-seq)
Through various approaches we demonstrate that SYCP1 is aberrantly re-expressed in tumor cells, where it actively promotes DNA damage repair, cell cycle progression, and malignant growth. SYCP1 binds chromatin at regulatory elements and directly controls transcriptional programs governing genome mai...
ORGANISM(S): Homo sapiens 
2026-03-15 | E-MTAB-15849 | biostudies-arrayexpress
UnknownStructural basis of meiotic chromosome synapsis through SYCP1 self-assembly.
Not available
S-EPMC6606445 | biostudies-literature
UnknownSYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis.
Not available
S-EPMC10588951 | biostudies-literature
UnknownDistinct cellular and reproductive consequences of meiotic chromosome synapsis defects in syce2 and sycp1 mutant zebrafish.
Not available
S-EPMC12425308 | biostudies-literature
UnknownSycp1 Is Not Required for Subtelomeric DNA Double-Strand Breaks but Is Required for Homologous Alignment in Zebrafish Spermatocytes.
Not available
S-EPMC8033029 | biostudies-literature
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