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TranscriptomicsTranscription profiling of mouse cerebral cortex using two model strains (C57BL/6 and ApoE(-/-) on the C57BL background) upon episode hypoxia treatment
Study the gene expression variation at cerebral cortex using two mouse model strains (C57BL/6 and ApoE(-/-) on the C57BL background) upon episode hypoxia treatment
ORGANISM(S): Mus musculus 
2013-01-30 | E-TIGR-135 | biostudies-arrayexpress
UnknownSelective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma.
Purpose Selinexor, a first-in-class, oral, selective exportin 1 (XPO1) inhibitor, induces apoptosis in cancer cells through nuclear retention of tumor suppressor proteins and the glucocorticoid receptor, along with inhibition of translation of oncoprotein mRNAs. We studied selinexor in combination w...
S-EPMC6905485 | biostudies-literature
UnknownA meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.
Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative subtypes. To identify additional genetic variants for ER-negative breast cancer, we conducted the largest meta-analysis of E...
S-EPMC3510753 | biostudies-literature
UnknownEvaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry.
Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive ability than PRSs based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several GW-PRS approaches to a recently developed PRS of 269 established prostate canc...
S-EPMC10357473 | biostudies-literature
UnknownA common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.
Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-n...
S-EPMC3279120 | biostudies-literature
UnknownA Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry.
A rare African ancestry-specific germline deletion variant in HOXB13 (X285K, rs77179853) was recently reported in Martinican men with early-onset prostate cancer. Given the role of HOXB13 germline variation in prostate cancer, we investigated the association between HOXB13 X285K and prostate cancer ...
S-EPMC9018520 | biostudies-literature
UnknownFour consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards.
The 'Sepsis Six' bundle was promoted as a deliverable tool outside of the critical care settings, but there is very little data available on the progress and change of sepsis care outside the critical care environment in the UK. Our aim was to compare the yearly prevalence, outcome and the Sepsis Si...
S-EPMC8355110 | biostudies-literature
UnknownEvidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry.

Background

Genetic factors play an important role in prostate cancer (PCa) susceptibility.

Objective

To discover common genetic variants contributing to the risk of PCa in men of African ancestry.

Design, setting, and participants

We conducted a meta-analysis of ten genome-wide...
S-EPMC10424812 | biostudies-literature
UnknownTrans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independ...
S-EPMC8148035 | biostudies-literature
UnknownCharacterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls...
S-EPMC10841479 | biostudies-literature
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