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UnknownTemporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability.
Not available
S-EPMC8700124 | biostudies-literature
GenomicsTranscriptome analysis of synaptosomes in ageing
Transcriptome analysis of synaptosomes in ageing
PRJNA1183882 | ENA
UnknownAgeing promotes microglial accumulation of slow-degrading synaptic proteins.
Not available
S-EPMC12935553 | biostudies-literature
TranscriptomicsTranscriptome analysis of synaptosomes in ageing
An important hallmark of aging is the loss of proteostasis, which can lead to the formation of protein aggregates and mitochondrial dysfunction in neurons. Although it is well known that protein synthesis is finely regulated in the brain, especially at synapses, where mRNAs are locally translated in...
ORGANISM(S): Mus musculus 
2025-11-13 | GSE281453 | GEO
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
ProteomicsDeep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation
In order to understand the molecular underpinnings of the functional and morphological heterogeneity of synapses and their regulation during development it is essential to identify the set of proteins that form these structures. Here, we prepared cortical synaptosomal fractions from juvenile and adu...
ORGANISM(S): Mus musculus (Mouse) 
2014-08-28 | PXD000552 | Pride
Synapse proteome ageing 
UnknownThe impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis.
Not available
S-EPMC6752963 | biostudies-literature
TranscriptomicsCalorie restriction suppresses age-dependent hippocampal transcriptional signatures.
Calorie restriction (CR) enhances longevity and mitigates aging phenotypes in numerous species. Physiological responses to CR are cell-type specific and variable throughout the lifespan; however, the mosaic of molecular changes responsible CR benefits remain unclear, particularly in brain regions su...
ORGANISM(S): Mus musculus 
2015-07-14 | E-GEOD-69952 | biostudies-arrayexpress
ProteomicsMouse Model of Alzheimer’s Disease Demonstrates Differential Effects of Early Pathology on Various Brain Regions
Alzheimer’s disease (AD) is a chronic ageing related neurodegenerative disease which is characterized by loss of synapses and neurons in the vulnerable brain regions. Expression perturbations of amyloid β (Aβ) and tau protein in the brain are two hallmarks of AD. Aβ is abnormally generated from amyl...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-11 | PXD019192 | Pride
Proteomics Hippocampus Alzheimer’s disease Cerebellum Amyloid beta Cortex App/ps1 
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